Механизмы антиканцерогенного действия флавоноидов
https://doi.org/10.17650/2313-805X.2014.1.1.56-68
Аннотация
Целью представленного обзора является анализ механизмов антиканцерогенного действия флавоноидов и изоцианатов на примере ряда соединений, широко употребляемых в средней полосе. В обзоре приведены данные исследований антиканцерогенного действия этих соединений в экспериментах in vitro и in vivo, рассмотрены мишени ингибирования действия химических канцерогенов в цепи их метаболизма, антиоксидантные эффекты флавоноидов, влияние пищевых полифенолов на метаболизм канцерогенных соединений, процессы промоции канцерогенеза и прогрессии опухоли, регуляцию клеточного цикла, цитоскелет и подвижность
трансформированных клеток, индукцию апоптоза и неоангиогенез.
Ключевые слова
Об авторах
Г. А. Белицкий
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва
Россия
Россия
К. И. Кирсанов
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва
Россия
Россия
Е. А. Лесовая
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва
Россия
Россия
М. Г. Якубовская
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва
Россия
Россия
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Рецензия
Для цитирования:
Белицкий Г.А., Кирсанов К.И., Лесовая Е.А., Якубовская М.Г. Механизмы антиканцерогенного действия флавоноидов. Успехи молекулярной онкологии. 2014;1(1):56-68. https://doi.org/10.17650/2313-805X.2014.1.1.56-68
For citation:
Belitsky G.A., Kirsanov K.I., Lesovaya E.A., Yakubovskaya M.G. Mechanisms of carcinogenesis prevention by flavonoids. Advances in Molecular Oncology. 2014;1(1):56-68. (In Russ.) https://doi.org/10.17650/2313-805X.2014.1.1.56-68
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