Secreted protein YB-1 and its prognostic significance

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Abstract

The multifunctional protein YB-1 in prokaryotes and eukaryotes participates in various processes, among others performing the functions  of a regulator of transcription and translation of many genes. Intracellular localization and expression of YB-1 is an acknowledged prognostic marker for certain malignant tumors. However, it has recently become clear that YB-1 can be released from cells and present in body fluids, including inside vesicles. The review collected data on the secretion YB-1 (sYB-1) content in blood serum from patients with inflammatory diseases and various tumors. There is analyzed the influence of sYB-1 on normal and tumor cells. Data are presented that show that intracellular YB-1 and sYB-1 affect cells differently. The prognostic significance of sYB-1 and its form YB-1/p18 in malignant neoplasms is discussed.

About the authors

A. A. Stavrovskaya

Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Author for correspondence.
Email: fake@neicon.ru
24 Kashirskoye Shosse, Moscow 115478. Russian Federation

N. I. Moiseeva

Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: Moiseeva@gmail.com
24 Kashirskoye Shosse, Moscow 115478. Russian Federation

G. P. Guens

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia.

Email: fake@neicon.ru
Build. 1, 20 Delegatskaya St., Moscow 127473. Russian Federation

E. Yu. Rybalkina

Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: fake@neicon.ru
24 Kashirskoye Shosse, Moscow 115478. Russian Federation

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