Pharmacogenetic testing of allelic variants of the CYP2D6 gene in hormone positive breast cancer

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Abstract

Tamoxifen is the drug of choice for endocrine therapy of hormone receptor- positive breast cancer in women in the reproductive period.  The metabolic activity of tamoxifen is determined by the activity of the enzyme CYP2D6, encoded by the gene of the same name: under  the action of the enzyme, tamoxifen passes into the metabolically active form, endoxyphene. Pharmacogenetic testing of the CYP2D6 gene  in patients with hormone-positive breast cancer can help predict the effectiveness of therapy and assess the risk of side effects with the aim  of improving long-term treatment outcomes.

About the authors

L. N. Lyubchenko

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Author for correspondence.
Email: clingen@mail.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

M. G. Filippova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

T. A. Shendrikova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

L. G. Zhukova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

N. I. Mekhtieva

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

O. V. Krokhina

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

S. M. Portnoy

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

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