Email this article Multidrug resistance of tumor cells: some new trends in research
- Authors: Stavrovskaya A.A.1, Guens G.P.2
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Affiliations:
- Federal State Budgetary Institution “N. N. Blokhin Russiаn Cancer Research Center”, Russian Academy of Medical Sciences, Moscow
- Department of Oncology and Radiology, Evdokimov State University of Medicine and Dentistry, Moscow
- Issue: Vol 1, No 1 (2014)
- Pages: 5-11
- Section: REVIEW ARTICLES
- Published: 02.06.2015
- URL: https://umo.abvpress.ru/jour/article/view/11
- DOI: https://doi.org/10.17650/2313-805X.2014.1.1.5-11
- ID: 11
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Abstract
Multidrug resistance (MDR) of tumor cells is the resistance to a broad spectrum of structurally unrelated cytotoxic drugs with different mechanisms of action. One of the main causes of MDR phenotype is the activity of ATP-binding cassette transporters (ABC transporters). ABC transporters efflux toxic compounds from the cells. All living cells contain ABC transporters. This review is dedicated to the studies of three-dimensional structure of ABC transporters, to the data concerning MDR evolution in tumor cell populations. Some information
about molecular mechanisms of MDR evolution is also presented.
About the authors
A. A. Stavrovskaya
Federal State Budgetary Institution “N. N. Blokhin Russiаn Cancer Research Center”, Russian Academy of Medical Sciences, Moscow
Author for correspondence.
Email: astavrovskaya@yahoo.com
Russian Federation
G. P. Guens
Department of Oncology and Radiology, Evdokimov State University of Medicine and Dentistry, Moscow
Email: fake@neicon.ru
Russian Federation
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