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Успехи молекулярной онкологии

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Роль Е-кадхерина в неопластической эволюции эпителиальных клеток

https://doi.org/10.17650/2313-805X.2014.1.1.12-17

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Аннотация

Трансмембранные белки кадхерины обеспечивают межклеточную адгезию через взаимодействие внеклеточных доменов. На протяжении многих лет эпителиальный Е-кадхерин считался опухолевым супрессором и рассматривался в качестве прогностического маркера у онкологических больных. Угнетение экспрессии Е-кадхерина наблюдали во многих карциномах. В последние несколько лет пересматриваются представления о супрессирующей оли Е-кадхерина. Показано, что протоковые карциномы молочной железы, карциномы толстой кишки, карциномы полости рта, плоскоклеточные карциномы головы и шеи могут сохранять экспрессию Е-кадхерина. При иммуногистохимическом окрашивании с использованием панели моноклональных антител во многих опухолях была выявлена мембранная локализация Е-кадхерина. В трансформированных эпителиоцитах in vitro были обнаружены динамичные межклеточные адгезионные контакты, образованные Е-кадхерином, которые важны для эффективной коллективной миграции клеток.

Об авторах

Н. А. Глушанкова
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва
Россия


И. Ю. Житняк
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва
Россия


Д. В. Айолло
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва
Россия


С. Н. Рубцова
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва
Россия


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Для цитирования:


Глушанкова Н.А., Житняк И.Ю., Айолло Д.В., Рубцова С.Н. Роль Е-кадхерина в неопластической эволюции эпителиальных клеток. Успехи молекулярной онкологии. 2014;1(1):12-17. https://doi.org/10.17650/2313-805X.2014.1.1.12-17

For citation:


Gloushankova N.A., Zhitnyak I.Y., Ayollo D.V., Rubtsova S.N. The role of E-cadherin in neoplastic evolution of epithelial cells. Advances in molecular oncology. 2014;1(1):12-17. (In Russ.) https://doi.org/10.17650/2313-805X.2014.1.1.12-17

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ISSN 2313-805X (Print)
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