STUDY OF THE LEVEL OF FATTY ACIDS IN ERYTHROCYTE MEMBRANES AND SERUM OF PATIENTS  WITH COLORECTAL CANCER IN NOVOSIBIRSK

M. V. Kruchinina; Кручинина М. В.; V. N. Kruchinin; Кручинин В. Н.; Ya. I. Prudnikova; Прудникова Я. И.; A. A. Gromov; Громов А. А.; M. V. Shashkov; Шашков М. В.; A. S. Sokolova; Соколова А. С.

doi:10.17650/2313-805X-2018-5-2-50-61

STUDY OF THE LEVEL OF FATTY ACIDS IN ERYTHROCYTE MEMBRANES AND SERUM OF PATIENTS WITH COLORECTAL CANCER IN NOVOSIBIRSK

Authors: Kruchinina M.V.¹^,2, Kruchinin V.N.³, Prudnikova Y.I.¹, Gromov A.A.¹, Shashkov M.V.⁴, Sokolova A.S.⁵
Affiliations:
1. Research Institute of Therapy and Preventive Medicine – a branch of the Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences
2. Novosibirsk State Medical University, Ministry of Health of Russia
3. A.V. Rzhanov Institute of Semiconductor Physics of the Siberian Branch of the Russian Academy of Sciences
4. G.K. Boreskov Institute of Catalysis of the Siberian Branch of the Russian Academy of Sciences
5. N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry
Issue: Vol 5, No 2 (2018)
Pages: 50-61
Section: RESEARCH ARTICLES
Published: 18.07.2018
URL: https://umo.abvpress.ru/jour/article/view/148
DOI: https://doi.org/10.17650/2313-805X-2018-5-2-50-61
ID: 148

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Abstract
About the authors
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Abstract

The objective is to measure the level of fatty acids in erythrocyte membranes and serum of patients with colorectal cancer.

Materials and methods. The study group included 100 patients with diagnosed colorectal cancer (57 men and 43 women). The control group included 24 reasonably healthy people (14 men and 10 women) matched for age and sex, without malignant cancers or manifested pathology of the internal organs.

Results. Decreased levels of saturated, monounsaturated fatty acids and increased levels of polyunsaturated fatty acids (PUFAs) in erythrocyte membranes and serum (p <0.0001–0.05) were observed. The levels of omega-3 PUFAs in colorectal cancer exceeded the levels in healthy individuals both in erythrocyte membranes and in serum; for omega-6 PUFAs only a trend was observed. At the same time, the ratio of omega-6/omega-3 PUFAs in colorectal cancer was lower than in control (p <0.0001–0.002). The state of erythrocyte membranes more significantly and for more parameters characterized differences between the groups than serum. The most discriminating parameters between patients with colorectal cancer and healthy individuals both in erythrocyte membranes and serum were the levels of C20:2;11,14 (eicosadienoic), C20:3;8,11,14 (dihomo-γ-linolenic), C20:4;5,8,11,14 (eicosatetraenoic, arachidonic), C22:5;7,10,13,16,19 (docosapentaenoic), and C22:6;4,7,10,13,16,19 (docosahexaenoic) PUFAs.

Keywords

membrane fatty acids, polyunsaturated fatty acids, serum, erythrocytes, colorectal cancer

About the authors

M. V. Kruchinina

Research Institute of Therapy and Preventive Medicine – a branch of the Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences; Novosibirsk State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: kruchmargo@yandex.ru
ORCID iD: 0000-0003-0077-3823

175/1 B. Bogatkova St., Novosibirsk 630089; 52 Krasniy Prospekt, Novosibirsk 630091

Russian Federation

V. N. Kruchinin

A.V. Rzhanov Institute of Semiconductor Physics of the Siberian Branch of the Russian Academy of Sciences

Email: fake@neicon.ru
ORCID iD: 0000-0002-9905-9031

12 Acad. Lavrentieva Prospekt, Novosibirsk 630090

Russian Federation

Ya. I. Prudnikova

Research Institute of Therapy and Preventive Medicine – a branch of the Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

175/1 B. Bogatkova St., Novosibirsk 630089

Russian Federation

A. A. Gromov

Research Institute of Therapy and Preventive Medicine – a branch of the Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

175/1 B. Bogatkova St., Novosibirsk 630089

Russian Federation