Эпигенетическая регуляция экспрессии генов в вирус-ассоциированных опухолях человека
Аннотация
Опухоли, ассоциированные с вирусами, составляют около 20 % всех опухолей человека. До недавнего времени при исследовании молекулярных механизмов вирусного канцерогенеза основные усилия были направлены на генетические нарушения, вызываемые онкогенными вирусами в клетке. Успехи, достигнутые в понимании механизмов эпигенетической регуляции экспрессии генов, стимулировали исследования взаимодействия вирусов и клетки-хозяина на эпигенетическом уровне. В обзоре рассмотрены общие закономерности взаимодействия онкогенных вирусов с эпигенетической системой регуляции функционирования генома и специфические для каждого вируса особенности этого взаимодействия в процессе установления латентной инфекции и опухолевой трансформации. Исследования регуляции экспрессии вирусного генома эпигенетической системой клетки и, с другой стороны, нарушений этой системы вирусами вносят вклад в понимание механизмов вирусного канцерогенеза, выявление новых маркеров прогрессии опухолей и мишеней для таргетной терапии.
Об авторах
Н. П. Киселёва
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва
Россия
Россия
Л. Ф. Киселёв
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва
Россия
Россия
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Для цитирования:
Киселёва Н.П., Киселёв Л.Ф. Эпигенетическая регуляция экспрессии генов в вирус-ассоциированных опухолях человека. Успехи молекулярной онкологии. 2014;1(1):48-55. https://doi.org/10.17650/2313-805X.2014.1.1.48-55
For citation:
Kisseljova N.P., Kisseljov F.L. Epygenetic regulation of gene expression in virus-associated human tumors. Advances in molecular oncology. 2014;1(1):48-55. (In Russ.) https://doi.org/10.17650/2313-805X.2014.1.1.48-55
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