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Успехи молекулярной онкологии

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Эпигенетическая регуляция экспрессии генов в вирус-ассоциированных опухолях человека

https://doi.org/10.17650/2313-805X.2014.1.1.48-55

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Аннотация

Опухоли, ассоциированные с вирусами, составляют около 20 % всех опухолей человека. До недавнего времени при исследовании молекулярных механизмов вирусного канцерогенеза основные усилия были направлены на генетические нарушения, вызываемые онкогенными вирусами в клетке. Успехи, достигнутые в понимании механизмов эпигенетической регуляции экспрессии генов, стимулировали исследования взаимодействия вирусов и клетки-хозяина на эпигенетическом уровне. В обзоре рассмотрены общие закономерности взаимодействия онкогенных вирусов с эпигенетической системой регуляции функционирования генома и специфические для каждого вируса особенности этого взаимодействия в процессе установления латентной инфекции и опухолевой трансформации. Исследования регуляции экспрессии вирусного генома эпигенетической системой клетки и, с другой стороны, нарушений этой системы вирусами вносят вклад в понимание механизмов вирусного канцерогенеза, выявление новых маркеров прогрессии опухолей и мишеней для таргетной терапии.

Об авторах

Н. П. Киселёва
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва
Россия


Л. Ф. Киселёв
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва
Россия


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Для цитирования:


Киселёва Н.П., Киселёв Л.Ф. Эпигенетическая регуляция экспрессии генов в вирус-ассоциированных опухолях человека. Успехи молекулярной онкологии. 2014;1(1):48-55. https://doi.org/10.17650/2313-805X.2014.1.1.48-55

For citation:


Kisseljova N.P., Kisseljov F.L. Epygenetic regulation of gene expression in virus-associated human tumors. Advances in molecular oncology. 2014;1(1):48-55. (In Russ.) https://doi.org/10.17650/2313-805X.2014.1.1.48-55

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ISSN 2313-805X (Print)
ISSN 2413-3787 (Online)