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Успехи молекулярной онкологии

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Современные представления о серологических опухолеассоциированных маркерах и их месте в онкологии

https://doi.org/10.17650/2313-805X.2014.1.1.69-80

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Аннотация

Обзор посвящен современным представлениям о серологических опухолеассоциированных маркерах (ОМ) и их месте в онкологии: использовании для дифференциальной диагностики, в прогнозе течения опухолевого процесса, мониторинге и для доклинического выявления рецидивов болезни, а также в скрининге, направленном на раннее выявление злокачественных новообразований. Описаны биохимические характеристики и функции наиболее информативных ОМ (СА125, ПСА и др). В настоящее время с целью повышения диагностической точности в лабораторной практике начинают применяться диагностические индексы, полученные путем многопараметрического анализа in vitro (in vitro diagnostic multivariate index assay, IVDMIA), 
и алгоритмы с использованием нескольких серологических маркеров. Также в обзоре описаны некоторые новые перспективные серологические ОМ.

Об авторах

Н. С. Сергеева
ФГБУ «Московский научно-исследовательский онкологический институт им. П. А. Герцена» Минздрава России
Россия


Н. В. Маршутина
ФГБУ «Московский научно-исследовательский онкологический институт им. П. А. Герцена» Минздрава России
Россия


М. П. Солохина
ФГБУ «Московский научно-исследовательский онкологический институт им. П. А. Герцена» Минздрава России
Россия


И. И. Алентов
ФГБУ «Московский научно-исследовательский онкологический институт им. П. А. Герцена» Минздрава России
Россия


Н. К. Парилова
ФГБУ «Московский научно-исследовательский онкологический институт им. П. А. Герцена» Минздрава России
Россия


Е. В. Зенкина
ФГБУ «Московский научно-исследовательский онкологический институт им. П. А. Герцена» Минздрава России
Россия


Т. Е. Скачкова
ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Минздрава России, Москва
Россия


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Сергеева Н.С., Маршутина Н.В., Солохина М.П., Алентов И.И., Парилова Н.К., Зенкина Е.В., Скачкова Т.Е. Современные представления о серологических опухолеассоциированных маркерах и их месте в онкологии. Успехи молекулярной онкологии. 2014;1(1):69-80. https://doi.org/10.17650/2313-805X.2014.1.1.69-80

For citation:


Sergeeva N.S., Marshutina N.V., Solokhina M.P., Alentov I.I., Parilova N.K., Zenkina E.V., Skashchkova T.E. Modern conceptions of serological tumor markers and their role in oncology. Advances in molecular oncology. 2014;1(1):69-80. (In Russ.) https://doi.org/10.17650/2313-805X.2014.1.1.69-80

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ISSN 2313-805X (Print)
ISSN 2413-3787 (Online)