Белки CRABP – родственники или однофамильцы?
Аннотация
Ретиноевая кислота (РК) – наиболее активный метаболит витамина А (ретинола), регулирующий широкий спектр физиологических процессов в организме, в том числе эмбриональное развитие, формирование иммунного ответа, гемопоэз, метаболизм глюкозы и липидов и др. РК участвует в регуляции важнейших аспектов жизнедеятельности клеток, включая дифференцировку, пролиферацию и программируемую клеточную гибель. Обзор посвящен сравнению 2 высокогомологичных представителей семейства внутриклеточных липидсвязывающих белков CRABP1 и CRABP2, основная и единственно установленная на сегодняшний день функция которых – внутриклеточное связывание РК. Однако значение данного связывания, по-видимому, различно. Связывание СRABP2 с РК приводит к активации ядерных рецепторов (RAR / RXR), являющихся транскрипционными факторами, и последующей стимуляции экспрессии целого ряда ретиноид-респонсивных генов. Значение связывания CRABP1 с РК менее понятно. Есть свидетельства сходного действия белков CRABP1 и CRABP2 в отношении усиления эффекта РК, однако большая часть данных указывает на противоположную роль CRABP1 – снижение внутриклеточной концентрации и / или уменьшение биодоступности РК за счет усиления ее метаболизма или секвестрирования в цитоплазме. Результаты последних исследований указывают на то, что у белков СRABP могут быть функции, не связанные с проведением сигнала от РК. Также противоречивы данные о роли этих белков в канцерогенезе и опухолевой прогрессии. В обзоре рассматриваются функции РК и молекулярные механизмы, опосредующие ее активность, включая различные аспекты функционирования рецепторов РК, приводится сравнительный анализ структурно-функциональных характеристик белков CRABP и рассматриваются возможные механизмы их внутриклеточной активности, как связанные с РК, так и независимые от ретиноевого сигналинга. Особое внимание уделено анализу данных о связи белков CRABP с канцерогенезом и их участию в опухолевой прогрессии, в том числе указывающих как на опухоль-супрессорную функцию, так и на протуморогенную активность.
Об авторах
Елена Максимовна Чевкина
ФГБНУ «Российский онкологический научный центр им. Н. Н. Блохина»
Россия
Научно-исследоательский институт канцерогенеза, Россия, 115478, Москва, Каширское шоссе, 24
Россия
Научно-исследоательский институт канцерогенеза, Россия, 115478, Москва, Каширское шоссе, 24
И. А. Фаворская
ФГБНУ «Российский онкологический научный центр им. Н. Н. Блохина»
Россия
Научно-исследоательский институт канцерогенеза, Россия, 115478, Москва, Каширское шоссе, 24
Россия
Научно-исследоательский институт канцерогенеза, Россия, 115478, Москва, Каширское шоссе, 24
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Для цитирования:
Чевкина Е.М., Фаворская И.А. Белки CRABP – родственники или однофамильцы? Успехи молекулярной онкологии. 2015;2(2):6-16. https://doi.org/10.17650/2313-805X.2015.2.2.6-16
For citation:
Tchevkina E.M., Favorskaya I.A. CRABP proteins – relatives or homonyms? Advances in molecular oncology. 2015;2(2):6-16. (In Russ.) https://doi.org/10.17650/2313-805X.2015.2.2.6-16
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