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Успехи молекулярной онкологии

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Роль мутаций в гене NF1 в спорадическом канцерогенезе

https://doi.org/10.17650/2313-805X-2021-8-3-25-33

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Аннотация

В обзорной статье представлены данные о роли соматической инактивации гена нейрофибромина NF1 в развитии спорадических злокачественных неоплазм. рассмотрена взаимосвязь особенностей опухолевого синдрома при нейрофиброматозе 1-го типа и специфических типов спорадических новообразований, при которых наиболее часто обнаруживают мутации в гене NF1. Описаны примеры химиорезистентности меланомы, нейробластомы, рака яичника, молочной железы и легких, обусловленной мутациями в этом гене (при условии отсутствия мутаций известных протоонкогенов). Для преодоления устойчивости к химиотерапии данных новообразований предложено использовать ингибиторы митоген-активируемой протеинкиназы, эффективность которых доказана при лечении плексиформных нейрофибром. представлены данные о взаимосвязи NF1 и микрорнк, которые могут быть применены в таргетной терапии нейрофиброматоза 1-го типа и спорадических неоплазм с мутациями данного гена. рассмотрены перспективы генной терапии данных заболеваний.

Об авторе

Р. Н. Мустафин
ФГБОУ ВО «Башкирский государственный медицинский университет»
Россия

450008 Уфа, ул. Ленина, 3



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Для цитирования:


Мустафин Р.Н. Роль мутаций в гене NF1 в спорадическом канцерогенезе. Успехи молекулярной онкологии. 2021;8(3):25-33. https://doi.org/10.17650/2313-805X-2021-8-3-25-33

For citation:


Mustafin R.N. The role of mutations in NF1 gene in sporadic carcinogenesis. Advances in Molecular Oncology. 2021;8(3):25-33. (In Russ.) https://doi.org/10.17650/2313-805X-2021-8-3-25-33

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