Эффективность иммунотерапии при разных злокачественных новообразованиях: обзор литературы
Аннотация
Известно, что иммунная система играет одну из основных ролей в развитии онкологии. Это подтверждается и тем, что пациенты с врожденным или приобретенным иммунодефицитом имеют более высокие риски развития рака. На сегодняшний день выделяют несколько видов иммунотерапии, каждый из которых имеет свой механизм действия. В этом обзоре представлены данные клинических исследований основных вариантов лечения, в основе которых лежат механизмы иммунотерапии, такие как клеточная иммунотерапия, применение антител и цитокинов, комбинированная иммунотерапия (с использованием чекпойнт-ингибиторов). Приведенные сведения свидетельствуют о положительной тенденции этого способа лечения у больных с онкологическими заболеваниями.
Ключевые слова
иммунотерапия,
клеточная иммунотерапия,
цитокины,
ингибиторы контрольных точек,
прогноз,
эффективность лечения
Об авторах
К. А. Гаптулбарова
Научно-исследовательский институт онкологии ФГБНУ «Томский национальный исследовательский медицинский центр» Российской академии наук; ФГАОУ ВО «Национальный исследовательский Томский государственный университет»
Россия
Россия
634009 Томск, Кооперативный пер., 5
634050 Томск, пр-т Ленина, 36
М. М. Цыганов
Научно-исследовательский институт онкологии ФГБНУ «Томский национальный исследовательский медицинский центр» Российской академии наук
Россия
Россия
Матвей Михайлович Цыганов
634009 Томск, Кооперативный пер., 5
М. К. Ибрагимова
Научно-исследовательский институт онкологии ФГБНУ «Томский национальный исследовательский медицинский центр» Российской академии наук; ФГАОУ ВО «Национальный исследовательский Томский государственный университет»
Россия
Россия
634009 Томск, Кооперативный пер., 5
634050 Томск, пр-т Ленина, 36
А. М. Певзнер
Научно-исследовательский институт онкологии ФГБНУ «Томский национальный исследовательский медицинский центр» Российской академии наук; ФГАОУ ВО «Национальный исследовательский Томский государственный университет»
Россия
Россия
634009 Томск, Кооперативный пер., 5
634050 Томск, пр-т Ленина, 36
Л. В. Спирина
Научно-исследовательский институт онкологии ФГБНУ «Томский национальный исследовательский медицинский центр» Российской академии наук
Россия
Россия
634009 Томск, Кооперативный пер., 5
Н. В. Литвяков
Научно-исследовательский институт онкологии ФГБНУ «Томский национальный исследовательский медицинский центр» Российской академии наук
Россия
Россия
634009 Томск, Кооперативный пер., 5
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Для цитирования:
Гаптулбарова К.А., Цыганов М.М., Ибрагимова М.К., Певзнер А.М., Спирина Л.В., Литвяков Н.В. Эффективность иммунотерапии при разных злокачественных новообразованиях: обзор литературы. Успехи молекулярной онкологии. 2021;8(4):8-20. https://doi.org/10.17650/2313-805X-2021-8-4-8-20
For citation:
Gaptulbarova K.A., Tsyganov M.M., Ibragimova M.K., Pevzner A.M., Spirina L.V., Litviakov N.V. Efficiency in different immunotherapy of cancer: literature review. Advances in Molecular Oncology. 2021;8(4):8-20. (In Russ.) https://doi.org/10.17650/2313-805X-2021-8-4-8-20
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