Preview

Успехи молекулярной онкологии

Расширенный поиск

Ассоциация рака молочной железы с онкогенными папилломавирусами: обнаружение ДНК папилломавирусов в клетках рака молочной железы

https://doi.org/10.17650/2313-805X-2022-9-2-10-22

Аннотация

Рак молочной железы – одна из острейших проблем здравоохранения во всем мире. Заболеваемость им растет. Развитие этого злокачественного новообразования связано со многими факторами риска, однако первопричина заболевания в большинстве случаев остается невыясненной. Исследования, посвященные ассоциации рака молочной железы с онкогенными папилломавирусами, проводятся на протяжении трех десятилетий, но однозначного заключения по данной проблеме пока нет. Актуальность вопроса об ассоциации с этими вирусами рака молочной железы многократно возрастает с появлением профилактических вакцин против рака шейки матки: в случае, если такая ассоциация имеет место, становится реальной перспектива предупреждения также и этой чрезвычайно распространенной формы рака.

Об авторе

Г. М. Волгарева
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России
Россия

Галина Михайловна Волгарева

115478 Москва, Каширское шоссе, 24



Список литературы

1. Bray F., Ferlay J., Soerjomataram I. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68(6):394–424. DOI: 10.3322/caac.21492.

2. Злокачественные новообразования в России в 2009 году (заболеваемость и смертность). Под ред. В.И. Чиссова, В.В. Старинского, Г.В. Петровой. М.: ФГБУ «МНИОИ им. П.А. Герцена» Минздрава России, 2011. 260 с.

3. Злокачественные новообразования в России в 2018 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М.: ФГБУ «МНИОИ им. П.А. Герцена» Минздрава России, 2019. 250 с.

4. Число умерших по причинам смерти в 2020 г. в Российской Федерации. Документ с сайта rosstat.gov.ru.

5. McPherson K., Steel C.M., Dixon J.M. ABC of breast diseases. Breast cancer – epidemiology, risk factors, and genetics. BMJ 2000;321(7261):624–8. DOI: 10.1136/bmj.321.7261.624.

6. Jakesz R. Breast cancer in developing countries: challenges for multidisciplinary care. Breast Care (Basel) 2008;3(1):4–5. DOI: 10.1159/000115969.

7. Kohler B.A., Sherman R.L., Howlader N. et al. Annual report to the nation on the status of cancer, 1975–2011. Featuring incidence of breast cancer subtypes by race/ethnicity, poverty, and state. J Natl Cancer Inst 2015;107(6): djv048. DOI: 10.1093/jnci/djv048.

8. Bittner J.J. Some possible effects of nursing on the mammary gland tumor incidence in mice. Science 1936;84(2172):162. DOI: 10.1126/science.84.2172.162.

9. Bittner J.J. Bertner Foundation Lecture: Studies on mammary cancer in mice and their implications for the human problem. Tex Rep Biol Med 1957;15(3):659–73.

10. Nartey T., Mazzanti C.M., Melana S., Glenn W.K. Mouse mammary tumor-like virus (MMTV) is present in human breast tissue before development of virally associated breast cancer. Infect Agent Cancer 2017;12:1. DOI: 10.1186/s13027-016-0113-6.

11. Huo Q., Zhang N., Yang Q. Epstein-Barr virus infection and sporadic breast cancer risk: a meta-analysis. PloS one 2012;7(2):e31656. DOI: 10.1371/journal.pone.0031656.

12. Golrokh Mofrad M., Kazeminezhad B., Faghihloo E. Prevalence of Epstein-Barr virus (EBV) in Iranian breast carcinoma patients. Asian Pac J Cancer Prev 2020;21(1):133–7. DOI: 10.31557/APJCP.2020.21.1.133.

13. Zur Hausen H. Papillomaviruses in the causation of human cancer – a brief historical accaunt. Minireview. Virology 2009;384(2):260–5. DOI: 10.1016/j.virol.2008.11.046.

14. IARC (International Agency for Research on Cancer, World Health Organization) Monographs on the evaluation of carcinogenic risks to humans. Vol. 90. Human Papillomaviruses. Lyon, 2007. 672 p.

15. IARC Monographs on the evaluation of carcinogenic risks to humans. Vol. 64. Human Papillomaviruses. Lyon, 1995. 6 p.

16. IARC Monographs on the evaluation of carcinogenic risks to humans. Vol.100. A review of human carcinogens. Part B. Biological agents. Lyon, 2011. Pp. 261–320.

17. Волгарева Г.М. Папилломавирусный канцерогенез. Основные достижения и некоторые проблемы. Ч. 1. Общие представления о папилломавирусах. Формы рака, ассоциированные с вирусами папилломы человека. Российский биотерапевтический журнал 2020;19(1):6–12.

18. Zur Hausen H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst 2000;92(9):690–8. PMID: 10793105. DOI: 10.1093/jnci/92.9.690.

19. Dyson N., Howley P.M., Münger K. et al. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 1989;243(4893):934–7. DOI: 10.1126/science.2537532.

20. Werness B.A., Levine A.J., Howley P.M. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 1990;248(4951):76–9. DOI: 10.1126/science.2157286.

21. Duensing S., Lee L.Y., Duensing A. et al. The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. Proc Natl Acad Sci USA 2000;97(18):10002–7. DOI: 10.1073/pnas.170093297.

22. Di Lonardo A., Venuti A., Marcante M.L. Human papillomavirus in breast cancer. Breast Cancer Res Treat 1992;21(2):95–100. DOI: 10.1007/BF01836955.

23. Zur Hausen H. Papillomaviruses – to vaccination and beyond. Biochemistry (Mosc) 2008;73(5):498–503. DOI:10.1134/S0006297908050027.

24. Kombe A.J., Li B., Zahid A. et al. Epidemiology and burden of human papillomavirus and related diseases, molecular pathogenesis, and vaccine evaluation. Front Public Health 2021;8:552028. DOI: 10.3389/fpubh.2020.552028.

25. Wrede D., Luqmani Y.A., Coombes R.C., Vousden K.H. Absence of HPV 16 and 18 DNA in breast cancer. Br J Cancer 1992;65(6):891–4. DOI: 10.1038/bjc.1992.186.

26. Hedau S., Kumar U., Hussain S. et al. Breast cancer and human papillomavirus infection: no evidence of HPV etiology of breast cancer in Indian women. BMC Cancer 2011;11:27. DOI: 10.1186/1471-2407-11-27.

27. Bakhtiyrizadeh S., Hosseini S.Y., Yaghobi R. et al. Almost complete lack of human cytomegalovirus and human papillomaviruses genome in benign and malignant breast lesions in Shiraz, southwest of Iran. Asian Path J Cancer Prev 2017;18(12):3319–24. DOI: 10.22034/APJCP.2017.18.12.3319.

28. Widschwendter A., Brunhuber T., Wiedemair A. et al. Detection of human papillomavirus DNA in breast cancer of patients with cervical cancer history. J Clin Virol 2004;31(4):292–7. DOI: 10.1016/j.jcv.2004.06.009.

29. De Villiers E.-M., Sandstrom R.E., zur Hausen H., Buck C.E. Presence of papillomavirus sequences in condylomatous lesions of the mammillae and in invasive carcinoma of the breast. Breast Cancer Res 2005;7(1):R1–11. DOI: 10.1186/bcr940.

30. Gumus M., Yumuk P., Salepci T. et al. HPV DNA frequency and subset analysis in human breast cancer patients’ normal and tumoral tissue samples. J Exp Clin Cancer Res 2006;25(4):515–21.

31. Kulka J., Kovalzsky I., Svastics E. et al. Lymphoepithelioma-like carcinoma of the breast: not Epstein-Barr virus, but human papilloma virus-positive. Hum Pathol 2008;39(2):298–301. DOI: 10.1016/j.humpath.2007.08.006.

32. Akil N., Yasmeen A., Kassab A. et al. High-risk human papillomavirus infections in breast cancer in Syrian women and their association with Id-1 expression: a tissue microarray study. Br J Cancer 2008;99(3):404–7. DOI: 10.1038/sj.bjc.6604503.

33. Delgado-Garcia S., Martinez- Escoriza J.-C., Alba A. et al. Presence of human papillomavirus DNA in breast cancer: a Spanish case-control study. BMC Cancer 2017;17(1):320. DOI: 10.1186/s12885-017-3308-3.

34. Lawson J.S., Glenn W.K., Salyakina D. et al. Human papilloma virus identification in breast cancer patients with previous cervical neoplasia. Front Oncol 2016;5:298. DOI: 10.3389/fonc.2015.00298.

35. Islam S., Dasgupta H., Roychowdhury A. et al. Study of association and molecular analysis of human papillomavirus in breast cancer of Indian patients: Clinical and prognostic implication. PLoS One 2017;12(2):e0172760. DOI: 10.1371/journal.pone.0172760.

36. Eklund C., Forslund O., Wallin K.L., Dillner J. Global improvement in genotyping of human papillomavirus DNA: the 2011 HPV LabNet International proficiency study. J Clin Microbiol 2014;52(2):449–59. DOI: 10.1128/JCM.02453-13.

37. Eklund C., Mühr L.S.A., Lagheden C. et al. The 2019 HPV Labnet international proficiency study: need of global Human Papillomavirus proficiency testing. J Clin Virol 2021;141:104902. DOI: 10.1016/j.jcv.2021.104902.

38. Khodabandehlou N., Mostafaei S., Etemadi A. et al. Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins. BMC Cancer 2019;19(1):61. DOI: 10.1186/s12885-019-5286-0.

39. Golrokh Mofrad M., Sadigh Z.A., Ainechi S., Faghihloo E. Detection of human papillomavirus genotypes, herpes simplex, varicella zoster and cytomegalovirus in breast cancer patients.Virol J 2021;18(1):25. DOI: 10.1186/s12985-021-01498-z.

40. Mirabello L., Clarke M.A. NCI HPV Workshop. The intersection of HPV epidemiology, genomics and mechanistic studies of HPV-mediated carcinogenesis. Viruses 2018;10(2):80. DOI: 10.3390/v10020080.

41. Hennig E.M., Suo Z., Thoresen S. et al. Human papillomavirus 16 in breast cancer of women treated for high grade cervical intraepithelial neoplasia (CIn III). Breast Cancer Res Treatment 1999;53(2):121–35. DOI: 10.1023/a:1006162609420.

42. Yu Y., Morimoto T., Sasa M. et al. Human papillomavirus type 33 DNA in breast cancer in Chinese. Breast Cancer 2000; 7(1):33–6. DOI: 10.1007/BF02967185.

43. Damin A., Karam R., Zettler C. et al. Evidence for an association of human papillomavirus and breast carcinomas. Breast Cancer Res Treatment 2004;84(2):131–7. DOI: 10.1023/B:BREA.0000018411.89667.0d.

44. Kroupis C., Markou A., Vourlidis N. et al. Presence of high-risk human papillomavirus sequences in breast cancer tissues and association with histopathological characteristics. Clin Biochem 2006;39(7):727–31. DOI: 10.1016/j.clinbiochem.2006.03.005.

45. Khan N.A., Castillo A., Koriyama C. et al. Human papillomavirus detected in female breast carcinomas in Japan. Br J Cancer 2008;99(3):408–14. DOI: 10.1038/sj.bjc.6604502.

46. Heng B., Glenn W.K., Ye Y. et al. Human papilloma virus is associated with breast cancer. Br J Cancer 2009;101(8):1345–50. DOI: 10.1038/sj.bjc.6605282.

47. Mendizabal-Ruiz A.P., Morales J.A., Ramirez-Jirano L.J. et al. Low frequency of human papillomavirus DNA in breast cancer tissue. Breast Cancer Res Treat 2009;114(1):189–94. DOI: 10.1007/s10549-008-9989-1.

48. Herrera-Goepfert R., Vela-Chavez T., Carrillo-Garcia A. et al. High-risk human papillomavirus (HPV) DNA sequences in metaplastic breast carcinomas of Mexican women. BMC Cancer 2013;13:445. DOI: 10.1186/1471-2407-13-445.

49. Fernandes A., Bianci G., Pesci Feltri A. et al. Presence of human papillomavirus in breast cancer and its association with prognostic factors. Ecamcermadicalscience 2015;9:548. DOI: 10.3332/ecancer.2015.548.

50. Gannon O.M., Antonsson A., Milevskiy M. et al. No association between HPV positive breast cancer and expression of human papilloma viral transcripts. Sci Rep 2015;5:18081. DOI: 10.1038/srep18081.

51. Choi J., Kim C., Lee H.S. et al. Detection of human papillomavirus in Korean breast cancer patients by real-time polymerase chain reaction and meta-analysis of human papillomavirus and breast cancer. J Pathol Transl Med 2016;50(6):442–50. DOI: 10.4132/jptm.2016.07.08.

52. Wang Y.-W., Zhang K., Zhao S. et al. HPV Status and its correlation with BCL2, p21, p53, Rb, and survivin expression in breast cancer in a chinese population. BioMed Res Int 2017;2017:6315392. DOI: 10.1155/2017/6315392.

53. Ngamkham J., Karalak A., Chaiwerawattana A. et al. Prevalence of Human Papillomavirus Infection in Breast Cancer Cells from Thai Women. Asian Pac J Cancer Prev 2017;18(7):1839–45. DOI: 10.22034/APJCP.2017.18.7.1839.

54. Bonlokke S., Blaakar J., Steiniche T. et al. Evidence of no association between human papillomavirus and breast cancer. Front Oncol 2018;8:209. DOI: 10.3389/fonc.2018.00209.

55. ElAmrani A., Gheit T., Benhessou M. et al. Prevalence of mucosal and cutaneous human papillomavirus in Moroccan breast cancer. Papillomavirus Res 2018;5:150–5. DOI: 10.1016/j.pvr.2018.04.003.

56. Cavalcante J.R., Pinheiro L.G.P., Almeida P.R.C. et al. Association of breast cancer with human papillomavirus (HPV) infection in Northeast Brazil: molecular evidence. Clinics (Sao Paulo) 2018;73:e465. DOI: 10.6061/clinics/2018/e465.

57. De Carolis S., Storci G., Ceccarelli C. et al. HPV DNA associates with breast cancer malignancy and it is transferred to breast cancer stromal cells by extracellular vesicles. Front Oncol 2019;9:860. DOI: 10.3389/fonc.2019.00860.

58. Sher G., Salman N.A., Kulinski M. et al. Prevalence and type distribution of highrisk human papillomavirus (HPV) in breast cancer: a Qatar based study. Cancers (Basel) 2020;12(6):1528. DOI: 10.3390/cancers12061528.

59. Biesaga B., Janecka-Widła A., Kołodziej-Rzepa M. et al. Low frequency of HPV positivity in breast tumors among patients from south-central Poland. Infect Agent Cancer 2021;16(1):67. DOI: 10.1186/s13027-021-00405-z.

60. Lawson J.S., Glenn W.K., Salyakina D. et al. Human papilloma viruses and breast cancer. Front Oncol 2015;5:277. DOI: 10.3389/fonc.2015.00277.

61. Krawczyk E., Suprynowicz F.A., Liu X., et al. Koilocytosis: a cooperative interaction between the human papillomavirus E5 and E6 oncoproteins. Am J Pathol 2008;173(3):682–8. DOI: 10.2353/ajpath.2008.080280.

62. Schwarz E., Freese U.K., Gissmann L. et al. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature 1985;314:111–4. DOI: 10.1038/314111a0.

63. Von Knebel Doeberitz M., Bauknecht T., Bartsch D., zur Hausen H. Influence of chromosomal integration on glucocorticoid-regulated transcription of growth-stimulating papillomavirus genes E6 and E7 in cervical carcinoma cells. Proc Natl Acad Sci USA 1991;88(4):1411–5. DOI: 10.1073/pnas.88.4.1411.

64. Klaes R., Woerner S.M., Ridder R. et al. Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res 1999;59(24):6132–6.

65. Ziegert C., Wentzensen N., Vinokurova S. et al. A comprehensive analysis of HPV integration loci in anogenital lesions combining transcript and genome-based amplification techniques. Oncogene 2003;22(25):3977–84. DOI: 10.1038/sj.onc.1206629.

66. Bodelon C., Untereiner M.E., Machiela M.J. et al. Genomic characterization of viral integration sites in HPV-related cancers. Int J Cancer 2016;139(9):2001–11. DOI: 10.1002/ijc.30243.27343048.

67. Aldersley J., Lorenz D.R., Mouw K.W. et al. Genomic landscape of primary and recurrent anal squamous cell carcinomas in relation to HPV integration, copy-number variation, and DNA damage response genes. Mol Cancer Res 2021;19(8):1308–21. DOI: 10.1158/1541-7786.MCR-20-0884.

68. Balaji H., Demers I., Wuerdemann N. et al. Causes and consequences of HPV integration in head and neck squamous cell carcinomas: state of the art. Cancers (Basel) 2021;13(16):4089. DOI: 10.3390/cancers13164089.

69. Huang K.B., Guo S.J., Li Y.H. et al. Genome-wide profiling reveals HPV integration pattern and activated carcinogenic pathways in penile squamous cell carcinoma. Cancers (Basel) 2021;13(23):6104. DOI: 10.3390/cancers13236104.

70. Burns M.B., Lackey L., Carpenter M.A. et al. APOBEC3B is an enzymatic source of mutation in breast cancer. Nature 2013;494(7437):366–70. DOI: 10.1038/nature11881.

71. Ohba K., Ichiyama K., Yajima M. et al. In vivo and in vitro studies suggest a possible involvement of HPV infection in the early stage of breast carcinogenesis via APOBEC3B induction. PLoS One 2014;9(5):e97787. DOI: 10.1371/journal.pone.0097787. PMID: 24858917.

72. Elagali A.M., Suliman A.A., Altayeb M. et al. Human papillomavirus, gene mutation and estrogen and progesterone receptors in breast cancer: a crosssectional study. Pan Afr Med J 2021;38:43. DOI: 10.11604/pamj.2021.38.43.22013.


Рецензия

Для цитирования:


Волгарева Г.М. Ассоциация рака молочной железы с онкогенными папилломавирусами: обнаружение ДНК папилломавирусов в клетках рака молочной железы. Успехи молекулярной онкологии. 2022;9(2):10-22. https://doi.org/10.17650/2313-805X-2022-9-2-10-22

For citation:


Volgareva G.M. Breast cancer association with oncogenic papillomaviruses: papillomaviral DNA detection in breast cancer cells. Advances in Molecular Oncology. 2022;9(2):10-22. (In Russ.) https://doi.org/10.17650/2313-805X-2022-9-2-10-22

Просмотров: 357


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2313-805X (Print)
ISSN 2413-3787 (Online)