Механизмы канцерогенного действия наноматериалов
Аннотация
Наноматериалы получают все большее распространение во многих областях жизни человека, формируя новую философию техносферы и, в частности, новые подходы к получению и использованию материалов в бытовых процессах, производстве, медицине и пр. Физико-химические характеристики наноматериалов существенно отличаются от соответствующих показателей агрегатных материалов и, по крайней мере, некоторые из них – высокой реакционноспособностью и / или повышенной каталитической активностью. Это позволяет предположить их агрессивность по отношению к биологическим системам, включая участие в процессах канцерогенеза.
В обзоре рассмотрены сферы использования современных наноматериалов, при этом особое внимание уделено описанию лекарственных препаратов, произведенных с использованием нанотехнологий, приведен анализ механизмов действия тех из них, которые уже признаны канцерогенными, а также представлены имеющиеся экспериментальные и механистические данные, полученные при изучении канцерогенного / проканцерогенного действия различных групп наноматериалов, не классифицируемых в настоящее время как представляющие канцерогенную опасность для человека.
При подготовке обзора был проведен анализ публикаций информационных баз биомедицинской литературы Scopus (507), PubMed (561), Web of Science (268), eLibrary.ru (190). Для получения полнотекстовых документов использованы электронные ресурсы PubMed Central (PMC), Science Direct, Research Gate, базы данных Sci-Hub и eLibrary.ru.
Об авторах
Г. А. Белицкий
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России
Россия
Россия
115522 Москва, Каширское шоссе, 24
К. И. Кирсанов
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России; ФГАОУ ВО «Российский университет дружбы народов»
Россия
Россия
115522 Москва, Каширское шоссе, 24
117198 Москва, ул. Миклухо-Маклая, 6
Е. А. Лесовая
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России; ФГБОУ ВО «Рязанский государственный медицинский университет им. акад. И. П. Павлова»
Россия
Россия
115522 Москва, Каширское шоссе, 24
390026 Рязань, ул. Высоковольтная, 9
М. Г. Якубовская
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава России
Россия
Россия
Марианна Геннадиевна Якубовская
115522 Москва, Каширское шоссе, 24
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Рецензия
При поддержке: Исследование выполнено при финансовой поддержке гранта Российского научного фонда (грант № 17-15-01526).
Для цитирования:
Белицкий Г.А., Кирсанов К.И., Лесовая Е.А., Якубовская М.Г. Механизмы канцерогенного действия наноматериалов. Успехи молекулярной онкологии. 2022;9(4):8‑23. https://doi.org/10.17650/2313-805X-2022-9-4-8-23
For citation:
Belitsky G.A., Kirsanov K.I., Lesovaya E.A., Yakubovskaya M.G. Mechanisms of the carcinogenicity of nanomaterials. Advances in Molecular Oncology. 2022;9(4):8‑23. (In Russ.) https://doi.org/10.17650/2313-805X-2022-9-4-8-23
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