Breast cancer association with oncogenic papillomaviruses: arguments pro and con
https://doi.org/10.17650/2313-805X-2023-10-1-18-24
Abstract
Possible breast cancer (BC) association with oncogenic human papilloma viruses (HPV) remains subject for discussion. DNA of these viruses was found in numerous BC samples in predominant majority of researches into the problem, that being the main argument in favour of their involvement into genesis of the given tumor. The principal objection to the opinion is that the HPV genomes number per a single cancer cell in HPV-positive BC is several orders of magnitude inferior to the similar indicator for cervical cancer. Urgency of the issue of possible BC association with oncogenic HPVs increases under the development of effective preventive vaccines against HPV infection. To clarify this matter the data might help either confirming or disproving the oncogenic HPV genome activity in DNA HPV-positive BC.
About the Author
G. M. Volgareva
N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Galina Mikhailovna Volgareva
24 Kashirskoe Shosse, Moscow 115522
References
1. Sung H., Ferlay J., Siegel R.L. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71(3):209–49. DOI: 10.3322/caac.21660
2. Siegel R.L., Miller K.D., Fuchs H.E., Jemal A. Cancer statistics, 2022. CA Cancer J Clin 2022;72(1):7–33. DOI: 10.3322/caac.21708
3. Украинец Р., Корнева Ю. Структура заболеваемости и смертности от злокачественных новообразований сегодня и прогноз на завтра. Онкология сегодня 2021;6(46):1–2. Ukrainets R., Korneva Yu. Malignant malformations’ incidence amd mortality structure and forecast. Onkologiya segodnya = Oncology Today 2021;6(46):1–2. (In Russ.).
4. Волгарева Г.М. Ассоциация рака молочной железы с онкогенными папилломавирусами: обнаружение ДНК папилломавирусов в клетках рака молочной железы. Успехи молекулярной онкологии 2022;9(2):10–22. DOI: 10.17650/2313-805X-2022-9-2-10-22. Volgareva G.M. Breast cancer association with oncogenic papillomaviruses: papillomaviral DNA detection in breast cancer cells. Uspekhi molekulyarnoy onkologii = Advances in Molecular Oncology 2022; 9(2):10–22. (In Russ.). DOI: 10.17650/2313-805X-2022-9-2-10-22
5. Khan N.A., Castillo A., Koriyama C. et al. Human papillomavirus detected in female breast carcinomas in Japan. Br J Cancer 2008;99(3):408–14. DOI: 10.1038/sj.bjc.6604502
6. Hedau S., Kumar U., Hussain S. et al. Breast cancer and human papillomavirus infection: no evidence of HPV etiology of breast cancer in Indian women. BMC Cancer 2011;11:27. DOI: 10.1186/1471-2407-11-27
7. Bakhtiyrizadeh S., Hosseini S.Y., Yaghobi R. et al. Almost complete lack of human cytomegalovirus and human papillomaviruses genome in benign and malignant breast lesions in Shiraz, Southwest of Iran. Asian Path J Cancer Prev 2017;18(12):3319–24. DOI: 10.22034/APJCP.2017.18.12.3319
8. Zur Hausen H. Papillomaviruses causing cancer: evasion from hostcell control in early events in carcinogenesis. J Natl Cancer Inst 2000;92(9):690–8. DOI: 10.1093/jnci/92.9.690
9. International Agency for Research on Cancer, World Health Organization. Monographs on the evaluation of carcinogenic risks to humans. Vol. 90. Human Papillomaviruses. Lyon, 2007. 672 p.
10. Band V., Zajchowski D., Kulesa V., Sager R. Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Proc Natl Acad Sci 1990; 87(1):463–7. DOI: 10.1073/pnas.87.1.463
11. Band V., De Caprio J.A., Delmolino L. et al. Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells. J Virol 1991;65(12):6671–6. DOI: 10.1128/JVI.65.12.6671-6676.1991.
12. Wazer D.E., Liu X.L., Chu Q. et al. Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7. Proc Natl Acad Sci 1995;92(9):3687–91 DOI: 10.1073/ pnas.92.9.3687
13. Волгарева Г.М. Папилломавирусный канцерогенез. Основные достижения и некоторые проблемы. Ч. 1. Общие представления о папилломавирусах. Формы рака, ассоциированные с вирусами папилломы человека. Российский биотерапевтический журнал 2020;19(1):6–12. DOI: 10.17650/1726-9784-2019-19-1-6-12 Volgareva G.M. Papillomaviral carcinogenesis. Major achievements and certain challenges. Part 1. General notions of papillomaviruses. Human papillomaviruses-associated cancers. Rossiiskii bioterapevticheskii zhurnal = Russian Biotherapeutic Journal 2020;19(1):6–12. (In Russ.) DOI: 10.17650/1726-9784-2019-19-1-6-12
14. Gannon O.M., Antonsson A., Milevskiy M. et al. No association between HPV positive breast cancer and expression of human papilloma viral transcripts. Sci Rep 2015;5:18081. DOI: 10.1038/ srep18081
15. Lawson J.S., Glenn W.K., Salyakina D. et al. Human papilloma viruses and breast cancer. Front Oncol 2015;5:277. DOI: 10.3389/fonc.2015.00277
16. Islam S., Dasgupta H., Roychowdhury A. et al. Study of association and molecular analysis of human papillomavirus in breast cancer of Indian patients: Clinical and prognostic implication. PLoS One 2017;12(2):e0172760. DOI: 10.1371/journal.pone.0172760
17. Khodabandehlou N., Mostafaei S., Etemadi A. et al. Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins. BMC Cancer 2019;19(1):61. DOI: 10.1186/s12885-019-5286-0
18. Akil N., Yasmeen A., Kassab A. et al. High-risk human papillomavirus infections in breast cancer in Syrian women and their association with Id-1 expression: a tissue microarray study. Br J Cancer 2008;99(3):404–7. DOI: 10.1038/sj.bjc.6604503
19. Lawson J.S., Glenn W.K., Salyakina D. et al. Human papilloma virus identification in breast cancer patients with previous cervical neoplasia. Front Oncol 2016;5:298. DOI: 10.3389/fonc.2015.00298
20. Salman N.A., Davies G., Majidy F. et al. Association of high risk human papillomavirus and breast cancer: a UK based study. Sci Rep 2017;7:43591. DOI: 10.1038/srep43591
21. Волгарева Г.М. Папилломавирусный канцерогенез. Основные достижения и некоторые проблемы. Ч. 3. Три уровня профилактики и лечения рака шейки матки. Российский биотерапевтический журнал 2020;19(3):6–11. DOI: 10.17650/1726-9784-2020-19-3-00-00 Volgareva G.M. Papillomaviral carcinogenesis. Major achievements and certain challenges. Part 3. Three levels of cervical cancer prevention and treatment. Rossiiskii bioterapevticheskii zhurnal = Russian Biotherapeutic Journal 2020;19(3):6–11. (In Russ.). DOI: 10.17650/1726-9784-2020-19-3-00-00
22. Biesaga B., Janecka-Widła A., Kołodziej-Rzepa M. et al. Low frequency of HPV positivity in breast tumors among patients from south-central Poland. Infect Agent Cancer 2021;16(1):67. DOI: 10.1186/s13027-021-00405-z
23. Dyson N., Howley P.M., Münger K., Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 1989;243(4893):934–7. DOI: 10.1126/science.2537532
24. Werness B.A., Levine A.J., Howley P.M. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 1990;248(4951):76–9. DOI: 10.1126/science.2157286
25. Wang Y.-W., Zhang K., Zhao S. et al. HPV status and its correlation with BCL2, p21, p53, Rb, and survivin expression in breast cancer in a Chinese population. BioMed Res Int 2017;2017:6315392. DOI: 10.1155/2017/6315392
26. Lin C.Q., Singh J., Murata K. et al. A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells. Cancer Res 2000;60(5):1332–40.
27. Jang K.-S., Han H.X., Paik S.S. et al. Id-1 overexpression in invasive ductal carcinoma cells is significantly associated with intratumoral microvessel density in ER-negative/node-positive breast cancer. Cancer Letters 2006;244(2):203–10. DOI: 10.1016/j.canlet.2005.12.016
28. Roschger C., Cabrele C. The Id-protein family in developmental and cancer-associated pathways. Cell Commun Signal 2017;15(1):7. DOI: 10.1186/s12964-016-0161-y
29. Zhao Z., Bo Z., Gong W., Guo Y. Inhibitor of differentiation 1 (Id1) in cancer and cancer therapy. Int J Med Sci 2020;17(8):95–1005. DOI: 10.7150/ijms.42805
30. Ohba K., Ichiyama K., Yajima M. et al. In vivo and in vitro studies suggest a possible involvement of HPV infection in the early stage of breast carcinogenesis via APOBEC3B induction. PLoS One 2014;9(5):e97787. DOI: 10.1371/journal.pone.0097787
31. Herrera-Goepfert R., Vela-Chavez T., Carrillo-Garcia A. et al. High-risk human papillomavirus (HPV) DNA sequences in metaplastic breast carcinomas of Mexican women. BMC Cancer 2013;13:445. DOI: 10.1186/1471-2407-13-445
32. Elagali A.M., Suliman A.A., Altayeb M. et al. Human papillomavirus, gene mutation and estrogen and progesterone receptors in breast cancer: a cross-sectional study. Pan Afr Med J 2021;38:43. DOI: 10.11604/pamj.2021.38.43.22013
33. Burns M.B., Lackey L., Carpenter M.A. et al. APOBEC3B is an enzymatic source of mutation in breast cancer. Nature 2013;494(7437):366–70. DOI: 10.1038/nature11881.
34. Stelzle D., Tanaka L.F., Lee K.K. et al. Estimates of the global burden of cervical cancer associated with HIV. Lancet Glob. Health 2021;9(2):e161–e169. DOI: 10.1016/S2214-109X(20)30459-9
35. Huo Z., Li C., Xu X. et al. Cancer risks in solid organ transplant recipients: results from a comprehensive analysis of 72 cohort studies. Oncoimmunology 2020;9(1):1848068. DOI: 10.1080/ 2162402X.2020.1848068
36. Park B., Yoon J., Kim H.J. et al. De novo cancer incidence after kidney and liver transplantation: results from a nationwide population based data. Sci Rep 2019;9(1):17202. DOI: 10.1038/s41598-019-53163-9
37. Goedert J.J., Schairer C., McNeel T.C. et al. Risk of breast, ovary, and uterine corpus concepts among 85268 women with AIDS. Br J Cancer 2006;95(5):642–8. DOI: 10.1038/sj.bjc.6603282
38. Grulich A.E., Vajdic C.M. The epidemiology of cancers in human immunodeficiency virus infection and after organ transplantation. Semin Oncol 2015;42(2):247–57. DOI: 10.1053/j.seminoncol.2014. 12.029
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Volgareva G.M. Breast cancer association with oncogenic papillomaviruses: arguments pro and con. Advances in Molecular Oncology. 2023;10(1):18-24. (In Russ.) https://doi.org/10.17650/2313-805X-2023-10-1-18-24
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