Mechanisms of action of plant polyphenols on the initiation of carcinogenesis

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Abstract

Genetic apparatus of human cells is constantly affected by a broad spectrum of mutagenic factors, both exogenous and endogenous. Genetic and epigenetic disorders, which emerge as a result of this influence, become the main cause of the majority of malignant neoplasias. Several different approaches were proposed to prevent these disorders, including the suppression of the activity of mutagenic factors by treatment with certain chemical compounds. Plant polyphenols are promising candidates for the development of chemopreventive drugs, as they exert the ability to regulate the metabolic activation of procarcinogens and modulate the cellular oxidative stress. In the present review, classification of plant phenolic compounds and their interactions  with biological macromolecules are described, along with the molecular mechanisms of their influence on the enzymes and regulatory pathways of phase I xenobiotic metabolism, and the prevention of oxidative stress. Interactions between natural polyphenols and patient’s microbiota is also described.

About the authors

A. V. Lyubitelev

Lomonosov Moscow State University

Author for correspondence.
Email: varanus.storri@gmail.com
ORCID iD: 0000-0003-0768-9309

Alexander V. Lyubitelev - Department of Bioengineering of Lomonosov Moscow State University.

Bld. 12, 1 Leninskie Gory, Moscow 119234

Russian Federation

A. L. Sivkina

Lomonosov Moscow State University

Email: fake@neicon.ru
ORCID iD: 0000-0002-4681-0178

Department of Bioengineering of Lomonosov Moscow State University.

Bld. 12, 1 Leninskie Gory, Moscow 119234

Russian Federation

O. A. Vlasova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-1498-849X

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

G. A. Belitsky

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-3167-7204

24 Kashirskoe Shosse, Moscow 115522

Russian Federation

V. M. Studitsky

Lomonosov Moscow State University; Fox Chase Cancer Center

Email: fake@neicon.ru
ORCID iD: 0000-0002-7389-7993

Department of Bioengineering of Lomonosov Moscow State University

Bld. 12, 1 Leninskie Gory, Moscow 119234; 333 Cottman Ave, Philadelphia 19111, Pennsylvania, USA

Russian Federation

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 57560 от  08.04.2014.