Механизмы действия растительных полифенолов на инициацию канцерогенеза

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Генетический аппарат клеток человеческого организма находится под постоянным воздействием большого спектра генотоксичных и негенотоксичных агентов, как экзогенных, так и эндогенных. возникающие в результате таких воздействий генетические и эпигенетические нарушения являются звеньями молекулярного патогенеза злокачественных новообразований. для профилактики развития таких нарушений предложены несколько различных подходов, включая подавление генотоксичного воздействия с помощью химических соединений. Благодаря способности оказывать влияние на активацию проканцерогенов и регуляцию окислительного стресса, растительные полифенольные соединения являются одними из перспективных кандидатов на роль химиопрофилактических антиканцерогенных препаратов. в обзоре рассмотрены структура и классификация полифенольных соединений и механизмы их взаимодействия с биологическими макромолекулами, а также молекулярные механизмы их влияния на ферменты, участвующие в 1-й фазе активации ксенобиотиков и регуляции окислительного стресса. Также проведен анализ эффектов природных полифенолов на микрофлору человека.

Об авторах

А. В. Любителев

ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»

Автор, ответственный за переписку.
Email: varanus.storri@gmail.com
ORCID iD: 0000-0003-0768-9309

Любителев Александр Викторович - кафедра биоинженерии ФГБОУ ВО «МГУ им. М.В. Ломоносова».

119234 Москва, Ленинские горы, 1, стр. 12

Россия

А. Л. Сивкина

ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»

Email: fake@neicon.ru
ORCID iD: 0000-0002-4681-0178

Кафедра биоинженерии ФГБОУ ВО «МГУ им. М.В. Ломоносова».

119234 Москва, Ленинские горы, 1, стр. 12

Россия

О. А. Власова

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России

Email: fake@neicon.ru
ORCID iD: 0000-0002-1498-849X

115522 Москва, Каширское шоссе, 24

Россия

Г. A. Белицкий

ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России

Email: fake@neicon.ru
ORCID iD: 0000-0002-3167-7204

115522 Москва, Каширское шоссе, 24

Россия

В. М. Студитский

ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»; Fox Chase Cancer Center

Email: fake@neicon.ru
ORCID iD: 0000-0002-7389-7993

Кафедра биоинженерии ФГБОУ ВО «МГУ им. М.В. Ломоносова».

119234 Москва, Ленинские горы, 1, стр. 12; 333 Cottman Ave, Philadelphia 19111, Pennsylvania, USA

Россия

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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