Белки мембранных микродоменов и их участие в онкогенезе
Аннотация
Липидные рафты плазматических мембран формируются холестеролом, сфингомиелидами и гликосфинголипидами, а также различными белками. Эти микродомены участвуют в различных клеточных процессах, таких как перестройка мембраны, интернализация белков, передача сигналов, через них осуществляется проникновение вирусов внутрь клетки. Часть липидных рафтов стабилизирована специальными микродоменобразующими белками (МОБ). На сегодняшний день известно несколько семейств таких белков: кавеолины, SPFH- семейство, тетраспанины, галектины, которые не только поддерживают целостность микродоменов, но и формируют «сигналосомы» и, таким образом, являются регуляторами многих сигнальных путей. Участие различных классов МОБ необходимо для нормального функционирования комплексов ростовых факторов с их рецепторами, регуляции интегринов, факторов реорганизации клеточного скелета и внеклеточного матрикса, везикулярного транспорта и т. д. МОБ вовлечены практически во все аспекты жизнедеятельности клетки, однако до сих пор классы МОБ принято рассматривать отдельно друг от друга. В представленном обзоре проведен анализ участия МОБ разных семейств в общих сигнальных путях, ассоциированных с канцерогенезом.
Об авторах
И. Б. Зборовская
Научно-исследовательский институт канцерогенеза ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России; Россия, 115478, Москва, Каширское шоссе, 24
Россия
Россия
С. А. Галецкий
Научно-исследовательский институт канцерогенеза ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России; Россия, 115478, Москва, Каширское шоссе, 24
Россия
Россия
А. В. Комельков
Научно-исследовательский институт канцерогенеза ФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» Минздрава России; Россия, 115478, Москва, Каширское шоссе, 24
Россия
Россия
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Для цитирования:
Зборовская И.Б., Галецкий С.А., Комельков А.В. Белки мембранных микродоменов и их участие в онкогенезе. Успехи молекулярной онкологии. 2016;3(3):16-29. https://doi.org/10.17650/2313-805X-2016-3-3-16-29
For citation:
Zborovskaya I.B., Galetskiy S.A., Komel’kov A.V. Microdomain forming proteins in oncogenesis. Advances in Molecular Oncology. 2016;3(3):16-29. (In Russ.) https://doi.org/10.17650/2313-805X-2016-3-3-16-29
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