Современные подходы к суицидальной генотерапии злокачественных новообразований
https://doi.org/10.17650/2313-805X-2024-11-2-63-73
Аннотация
Одним из перспективных направлений противоопухолевой терапии является суицидальная генотерапия, основанная на внедрении в опухолевые клетки цитотоксических генов. Чаще всего это гены ферментов бактериального или вирусного происхождения, способные напрямую или опосредованно уничтожать клетки опухоли. В настоящем обзоре представлены сведения о современных стратегиях суицидальной генотерапии злокачественных новообразований, описаны их достоинства и недостатки, а также проанализированы свойства потенциального кандидата для создания на его основе новой высокоэффективной суицидальной системы, совмещающей в себе достоинства уже существующих подходов.
При поддержке: Работа выполнена при финансовой поддержке Российского научного фонда (проект № 21-74-10036) в рамках Программы стратегического академического лидерства ФГАОУ ВО «Казанский (Приволжский) федеральный университет» («Приоритет-2030»)
Об авторах
Е. В. Дудкина
ФГАОУ ВО «Казанский (Приволжский) федеральный университет»
Россия
Россия
420008; ул. Кремлевская, 18; Казань
В. В. Ульянова
ФГАОУ ВО «Казанский (Приволжский) федеральный университет»
Россия
Россия
Вера Владимировна Ульянова
420008; ул. Кремлевская, 18; Казань
О. Н. Ильинская
ФГАОУ ВО «Казанский (Приволжский) федеральный университет»
Россия
Россия
420008; ул. Кремлевская, 18; Казань
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Рецензия
Для цитирования:
Дудкина Е.В., Ульянова В.В., Ильинская О.Н. Современные подходы к суицидальной генотерапии злокачественных новообразований. Успехи молекулярной онкологии. 2024;11(2):63-73. https://doi.org/10.17650/2313-805X-2024-11-2-63-73
For citation:
Dudkina E.V., Ulyanova V.V., Ilinskaya O.N. Modern approaches in suicidal gene therapy of malignant neoplasms. Advances in Molecular Oncology. 2024;11(2):63-73. (In Russ.) https://doi.org/10.17650/2313-805X-2024-11-2-63-73
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