Иммунологическая толерантность при раке молочной железы: некоторые причины развития
https://doi.org/10.17650/2313-805X-2024-11-3-24-31
Аннотация
Иммунологическая толерантность является одной из причин возникновения и прогрессирования злокачественных опухолей. Противоопухолевый иммунный цикл регулирует нормальный противоопухолевый иммунный ответ, а его нарушение вызывает развитие иммунологической толерантности. В статье представлен обзор отечественной и зарубежной литературы, опубликованной за последние 5 лет в базах PubMed, Medline, Cochrane, eLibrary и посвященой вопросам возникновения иммунологической толерантности при раке молочной железы с позиции нарушения регуляции фаз противоопухолевого иммунного цикла. В настоящее время выделяют следующие этапы противоопухолевого иммунного цикла: экспрессия антигенов на поверхности опухолевых клеток, созревание антигенпрезентирующих клеток и распознавание опухолевых антигенов, праймирование и активация Т-клеток, иммунная инфильтрация опухолевого очага, распознавание и уничтожение опухолевых клеток. Понимание механизмов, лежащих в основе противоопухолевого иммунного цикла, важно для выявления новых иммунопатогенетических звеньев развития рака молочной железы и таргетируемых мишеней с целью улучшения эффективности терапии распространенного рака молочной железы.
Об авторах
Е. В. Каюкова
ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России
Россия
Россия
672000 Чита, ул. Горького, 39А
Э. С. Болотов
ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России
Россия
Россия
Элбэк Саянович Болотов
672000 Чита, ул. Горького, 39А
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Рецензия
Для цитирования:
Каюкова Е.В., Болотов Э.С. Иммунологическая толерантность при раке молочной железы: некоторые причины развития. Успехи молекулярной онкологии. 2024;11(3):24-31. https://doi.org/10.17650/2313-805X-2024-11-3-24-31
For citation:
Kayukova E.V., Bolotov E.S. Immunological tolerance in breast cancer: some reasons for development. Advances in Molecular Oncology. 2024;11(3):24-31. (In Russ.) https://doi.org/10.17650/2313-805X-2024-11-3-24-31
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