The role of methionine cycle disruption in the initiation and progression of malignant tumors

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Abstract

The methionine cycle is responsible for the metabolism of substances associated with methionine, one of the essential amino acids for protein synthesis. The methionine cycle dysregulation leads to non-proteinogenic amino acid homocysteine accumulation that can have a negative impact on a health. Numerous studies describe homocysteine effect on cardiovascular pathology development but its role in carcinogenesis remains poorly understood. Therefore, the purpose of this review is to analyze scientific data regarding the role of methionine catabolism dysregulation in a cell neoplastic transformation and tumor growth. Understanding cellular alterations of methionine metabolism is important for novel anti-cancer drugs development as well as establishing approaches for combinatorial treatment strategies aiming to overcome metabolic plasticity of cancer cells and their drug resistance.

About the authors

T. G. Ruksha

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Author for correspondence.
Email: tatyana_ruksha@mail.ru
ORCID iD: 0000-0001-8142-4283

Tatiana Gennadievna Ruksha

1 Partizanа Zheleznyakа St., Krasnoyarsk 660022

Russian Federation

M. N. Kurbat

Grodno State Medical University

Email: fake@neicon.ru
ORCID iD: 0000-0002-8518-2450

80 Gorkogo St., Grodno 230009

Belarus

N. V. Palkina

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Email: fake@neicon.ru
ORCID iD: 0000-0002-6801-3452

1 Partizanа Zheleznyakа St., Krasnoyarsk 660022

Russian Federation

V. A. Kutsenko

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Email: fake@neicon.ru

1 Partizanа Zheleznyakа St., Krasnoyarsk 660022

Russian Federation

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