Баланс между обманом и адаптацией: васкулогенная мимикрия как стратегия выживания опухоли
https://doi.org/10.17650/2313-805X-2025-12-1-14-30
Аннотация
Васкулогенная мимикрия представляет собой уникальный процесс, при котором опухолевые клетки имитируют нормальные эндотелиальные клетки сосудов с целью обеспечения себе доступа к кровоснабжению. В настоящем обзоре рассмотрены молекулярные механизмы, предшествующие этому явлению, а также его важность в контексте развития солидных опухолей. Мы проанализировали стратегии выживания опухолевых клеток, использующих васкулогенную мимикрию, и описали потенциальные терапевтические подходы, направленные на подавление роста и метастазирования опухоли. Освещение методов гистологической и молекулярной идентификации васкулогенной мимикрии способствует лучшему пониманию данного феномена и его ранней диагностике. В обзоре акцентируется внимание на необходимости дальнейших исследований васкулогенной мимикрии для формирования представлений о механизмах, лежащих в основе канцерогенеза. Мы проанализировали результаты 109 работ, представленных в ведущих биомедицинских базах данных, включая SciVerse Scopus, PubMed, Web of Science и РИНЦ (Российский индекс научного цитирования), что позволило обобщить актуальные научные данные и выявить ключевые тенденции в области молекулярной онкологии.
Об авторах
Е. А. Просекина
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России
Россия
Россия
Елизавета Андреевна Просекина
Россия, 197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68
В. А. Шапкина
ФГБОУ ВО «Санкт-Петербургский государственный университет»
Россия
Россия
Россия, 199034 Санкт-Петербург, Университетская наб., 7/9
А. Е. Карпов
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России
Россия
Россия
Россия, 197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68
Е. Ю. Федоруцева
ФГАОУ ВО «Национальный исследовательский Томский государственный университет»
Россия
Россия
Россия, 634050 Томск, пр-кт Ленина, 36
А. С. Артемьева
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Петрова» Минздрава России
Россия
Россия
Россия, 197758 Санкт-Петербург, пос. Песочный, ул. Ленинградская, 68
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Рецензия
Для цитирования:
Просекина Е.А., Шапкина В.А., Карпов А.Е., Федоруцева Е.Ю., Артемьева А.С. Баланс между обманом и адаптацией: васкулогенная мимикрия как стратегия выживания опухоли. Успехи молекулярной онкологии. 2025;12(1):14-30. https://doi.org/10.17650/2313-805X-2025-12-1-14-30
For citation:
Prosekina E.A., Shapkina V.A., Karpov A.E., Fedorutseva E.Yu., Artemyeva A.S. The balance between deception and adaptation: vasculogenic mimicry as a tumor survival strategy. Advances in Molecular Oncology. 2025;12(1):14-30. (In Russ.) https://doi.org/10.17650/2313-805X-2025-12-1-14-30
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