The balance between deception and adaptation: vasculogenic mimicry as a tumor survival strategy
https://doi.org/10.17650/2313-805X-2025-12-1-14-30
Abstract
Vasculogenic mimicry is a unique process through which tumor cells imitate normal vascular endothelial cells to secure access to the blood flow. In this review, we consider molecular mechanisms underlying this phenomenon and its importance in the context of solid tumor development. We have analyzed survival strategies of tumor cells using vasculogenic mimicry and described potential therapeutic approaches aimed at tumor growth and metastasis suppression. Highlighting the methods of histological and molecular identification of vasculogenic mimicry promotes better understanding of this phenomenon and its early diagnosis. The review focuses on the necessity of further research in the area of vasculogenic mimicry to conceptualize mechanisms underlying carcinogenesis. We have analyzed 109 articles from the leading biomedical databases including SciVerse Scopus, PubMed, Web of Science and RSCI (Russian Science Citation Index) which allowed us to summarize current scientific data and identify the key trends in the area of molecular oncology.
About the Authors
E. A. Prosekina
N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
Elizaveta Andreevna Prosekina
68 Leningradskaya St., Pesochny Settlement, Saint Petersburg 197758, Russia
V. A. Shapkina
Saint Petersburg State University
Russian Federation
Russian Federation
7/9 Universitetskaya Emb., Saint Petersburg 199034, Russia
A. E. Karpov
N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
68 Leningradskaya St., Pesochny Settlement, Saint Petersburg 197758, Russia
E. Yu. Fedorutseva
National Research Tomsk State University
Russian Federation
Russian Federation
36 Lenin Prospekt, Tomsk 634050, Russia
A. S. Artemyeva
N.N. Petrov National Medical Research Center of Oncology, Ministry of Health of Russia
Russian Federation
Russian Federation
68 Leningradskaya St., Pesochny Settlement, Saint Petersburg 197758, Russia
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For citations:
Prosekina E.A., Shapkina V.A., Karpov A.E., Fedorutseva E.Yu., Artemyeva A.S. The balance between deception and adaptation: vasculogenic mimicry as a tumor survival strategy. Advances in Molecular Oncology. 2025;12(1):14-30. (In Russ.) https://doi.org/10.17650/2313-805X-2025-12-1-14-30
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