Laminins: role in invasion, metastasis, and prognosis of malignant neoplasms of various localizations

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Abstract

Laminins are a family of high-molecular-weight heterotrimeric glycoproteins of the extracellular matrix that play a key structural role in basement membranes. Although mutations in intracellular proteins remain the primary drivers of carcinogenesis, the role of changes in the expression and spatial distribution of laminins in the development of malignant neoplasms is gaining increasing importance. Primary focus is given to the patterns of laminin alterations in carcinomas of various localizations, as well as their role in the acquisition of invasive and metastatic potential by tumor cells. Furthermore, the prognostic significance of different laminin isoforms is discussed.

 

 

 

About the authors

M. V. Zavyalova

Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of the Russia

Email: pismenniy.dmitry@yandex.ru
ORCID iD: 0000-0001-9429-9813

Cancer Research Institute

 

Russian Federation, 5 Kooperativny Line, Tomsk 634009; 2 Moskovsky Trakt, Tomsk 634050

G. A. Kuznetsov

Siberian State Medical University, Ministry of Health of the Russia

Email: pismenniy.dmitry@yandex.ru
ORCID iD: 0000-0002-9443-7224
Russian Federation, 2 Moskovsky Trakt, Tomsk 634050

A. V. Zavyalov

Siberian State Medical University, Ministry of Health of the Russia

Email: pismenniy.dmitry@yandex.ru
ORCID iD: 0009-0009-0266-6707
Russian Federation, 2 Moskovsky Trakt, Tomsk 634050

Dmitry S. Pismenniy

Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of the Russia

Author for correspondence.
Email: pismenniy.dmitry@yandex.ru
ORCID iD: 0000-0001-8973-8439

Cancer Research Institute

Russian Federation, 5 Kooperativny Line, Tomsk 634009; 2 Moskovsky Trakt, Tomsk 634050

O. V. Pankova

Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: pismenniy.dmitry@yandex.ru
ORCID iD: 0000-0002-5510-1808

Cancer Research Institute

Russian Federation, 5 Kooperativny Line, Tomsk 634009

V. E. Popova

Siberian State Medical University, Ministry of Health of the Russia

Email: pismenniy.dmitry@yandex.ru
ORCID iD: 0009-0001-9740-7776
Russian Federation, 2 Moskovsky Trakt, Tomsk 634050

V. M. Perelmuter

Tomsk National Research Medical Center of the Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of the Russia

Email: pismenniy.dmitry@yandex.ru
ORCID iD: 0000-0002-7633-9620

Cancer Research Institute

 

Russian Federation, 5 Kooperativny Line, Tomsk 634009; 2 Moskovsky Trakt, Tomsk 634050

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