Heterogeneity and clonal evolution of colorectal cancer

There are a lot of studies that dedicated to genetic differences between the primary tumor and metastases. This becomes relevant not only for molecular biologists for understanding carcinogenesis, but also becoming increasingly important for medical oncologists, due to the possible impact on the choice of therapy for metastatic disease. In this regard, colon cancer is an interesting model for studying the heterogeneity of the primary tumor and possible clonal evolution, because we have predictive genetic markers for target therapy. In this article, we analyzed studies on the concordance of the mutation status of the genes, intratumoral heterogeneity and processes of clonal evolution in colorectal cancer.