Рак как следствие генетического мозаицизма
Аннотация
Вопреки устоявшемуся мнению о стабильной ДНК как носителе наследственной информации, в нормальной (а не только раковой) клетке геном подвержен непрерывным изменениям в результате различных воздействий: ошибок копирования (в процессе репликации), дефектов сегрегации хромосом (в митозе) и прямых химических атак (активными формами кислорода). Процесс генетической диверсификации клеток стартует в эмбриональном развитии и длится всю жизнь, порождая феномен соматического мозаицизма. Новые представления о генетическом разнообразии клеток организма заставляют в ином, чем ранее, ракурсе рассматривать проблемы этиологии, патогенеза и профилактики злокачественных новообразований.
Ключевые слова
Об авторе
А. В. Лихтенштейн
НИИ канцерогенеза ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России
Россия
115478 Москва, Каширское шоссе, 24
Россия
115478 Москва, Каширское шоссе, 24
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Для цитирования:
Лихтенштейн А.В. Рак как следствие генетического мозаицизма. Успехи молекулярной онкологии. 2017;4(2):26-35. https://doi.org/10.17650/2313-805X-2017-4-2-26-35
For citation:
Likhtensteyn A.V. Cancer as a result of genetic mosaicism. Advances in Molecular Oncology. 2017;4(2):26-35. (In Russ.) https://doi.org/10.17650/2313-805X-2017-4-2-26-35
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