IQGAP scaffold proteins are the multifunctional regulators of cellular signaling and malignant transformation

P. A. Skovorodnikova; Сковородникова П. А.; M. S. Chesnokov; Чесноков М. С.; A. A. Budko; Будко А. А.; I. F. Kustova; Кустова И. Ф.; N. L. Lazarevich; Лазаревич Н. Л.

doi:10.17650/2313-805X-2017-4-2-36-45

IQGAP scaffold proteins are the multifunctional regulators of cellular signaling and malignant transformation

Authors: Skovorodnikova P.A.¹^,2, Chesnokov M.S.¹, Budko A.A.¹^,2, Kustova I.F.¹, Lazarevich N.L.¹^,2
Affiliations:
1. Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
2. M.V. Lomonosov Moscow State University
Issue: Vol 4, No 2 (2017)
Pages: 36-45
Section: REVIEW ARTICLES
Published: 01.07.2017
URL: https://umo.abvpress.ru/jour/article/view/93
DOI: https://doi.org/10.17650/2313-805X-2017-4-2-36-45
ID: 93

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Abstract

Scaffold proteins coordinate the assembling of multicomponent protein complexes and participate in transduction of cellular signals via multiple signaling pathways therefore acting as important regulators of cell properties. IQ Motif Containing GTPase Activating Proteins (IQGAPs) are promising targets for studying the role of scaffold proteins in intracellular signaling regulation and development of cancer and other diseases. IQGAP family includes 3 proteins (IQGAP1, IQGAP2 and IQGAP3) that differ considerably by their expression patterns and functions. Distinct genomic aberrations and expression changes in various tumors were reported for all three IQGAP family members. The present paper thoroughly reviews the structure of IQGAP proteins, their involvement in regulation of cell characteristics and interactions with components of intracellular signaling pathways. Special attention is given to the up-to-date data on deregulation of IQGAP genes functions in different tumor types, analysis of their possible role in tumor progression and their associations with clinicopathological tumor characteristics.

Keywords

scaffold proteins, IQGAP, multiprotein complex, MAP-kinase cascade, Wnt signaling pathway, β-catenin, tumor progression, protooncogene, tumor suppressor

About the authors

P. A. Skovorodnikova

Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia;
M.V. Lomonosov Moscow State University

Email: fake@neicon.ru

24 Kashirskoye Shosse, Moscow 115478;

Biological Faculty, Build. 12, 1 Leninskie Gory, Moscow 119991

Russian Federation

M. S. Chesnokov

Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

Email: fake@neicon.ru
24 Kashirskoye Shosse, Moscow 115478 Russian Federation

A. A. Budko

Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia;
M.V. Lomonosov Moscow State University

Email: fake@neicon.ru

24 Kashirskoye Shosse, Moscow 115478;

Faculty of Fundamental Medicine, Build. 1, 27 Lomonosovskiy Prospekt, Moscow 119991

Russian Federation

I. F. Kustova

Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

Email: fake@neicon.ru
24 Kashirskoye Shosse, Moscow 115478 Russian Federation

N. L. Lazarevich

Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia;
M.V. Lomonosov Moscow State University

Author for correspondence.
Email: lazarevich.nl@gmail.com

24 Kashirskoye Shosse, Moscow 115478;

Biological Faculty, Build. 12, 1 Leninskie Gory, Moscow 119991

Russian Federation

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