IQGAP scaffold proteins are the multifunctional regulators of cellular signaling and malignant transformation
https://doi.org/10.17650/2313-805X-2017-4-2-36-45
Abstract
Scaffold proteins coordinate the assembling of multicomponent protein complexes and participate in transduction of cellular signals via multiple signaling pathways therefore acting as important regulators of cell properties. IQ Motif Containing GTPase Activating Proteins (IQGAPs) are promising targets for studying the role of scaffold proteins in intracellular signaling regulation and development of cancer and other diseases. IQGAP family includes 3 proteins (IQGAP1, IQGAP2 and IQGAP3) that differ considerably by their expression patterns and functions. Distinct genomic aberrations and expression changes in various tumors were reported for all three IQGAP family members. The present paper thoroughly reviews the structure of IQGAP proteins, their involvement in regulation of cell characteristics and interactions with components of intracellular signaling pathways. Special attention is given to the up-to-date data on deregulation of IQGAP genes functions in different tumor types, analysis of their possible role in tumor progression and their associations with clinicopathological tumor characteristics.
About the Authors
P. A. Skovorodnikova
Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia;
M.V. Lomonosov Moscow State University
Russian Federation
Russian Federation
24 Kashirskoye Shosse, Moscow 115478;
Biological Faculty, Build. 12, 1 Leninskie Gory, Moscow 119991
M. S. Chesnokov
Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Russian Federation
24 Kashirskoye Shosse, Moscow 115478
Russian Federation
24 Kashirskoye Shosse, Moscow 115478
A. A. Budko
Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia;
M.V. Lomonosov Moscow State University
Russian Federation
Russian Federation
24 Kashirskoye Shosse, Moscow 115478;
Faculty of Fundamental Medicine, Build. 1, 27 Lomonosovskiy Prospekt, Moscow 119991
I. F. Kustova
Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
Russian Federation
24 Kashirskoye Shosse, Moscow 115478
Russian Federation
24 Kashirskoye Shosse, Moscow 115478
N. L. Lazarevich
Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia;
M.V. Lomonosov Moscow State University
Russian Federation
Russian Federation
24 Kashirskoye Shosse, Moscow 115478;
Biological Faculty, Build. 12, 1 Leninskie Gory, Moscow 119991
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Review
For citations:
Skovorodnikova P.A., Chesnokov M.S., Budko A.A., Kustova I.F., Lazarevich N.L. IQGAP scaffold proteins are the multifunctional regulators of cellular signaling and malignant transformation. Advances in Molecular Oncology. 2017;4(2):36-45. (In Russ.) https://doi.org/10.17650/2313-805X-2017-4-2-36-45
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