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Успехи молекулярной онкологии

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Химиотерапия: возможные риски при обращении с противоопухолевыми препаратами

https://doi.org/10.17650/2313-805X-2017-4-3-10-20

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Аннотация

В России многочисленные контингенты работников, занятых в сфере здравоохранения, могут подвергаться воздействию противоопухолевых препаратов, многие из которых являются канцерогенными. Загрязнение рабочей среды медицинских работников лекарственными противоопухолевыми препаратами связано с функционированием всей внутрибольничной системы от этапа их доставки до утилизации медицинских отходов. Это подтверждается данными мониторинга загрязнения химиопрепаратами внутрибольничной среды с использованием современных методов анализа, выполненного в разных странах. Результат ежедневной и многолетней профессиональной экспозиции медицинского персонала к химиопрепаратам может реализоваться в виде цитотоксических эффектов, нарушения репродуктивной функции и повышения онкологического риска. Показано увеличение риска врожденных пороков развития у детей, спонтанных абортов у работниц при профессиональной экспозиции к цитостатикам. По данным эпидемиологических исследований, у женского персонала, имевшего контакт с этими препаратами, чаще наблюдалось повышение риска возникновения рака молочной железы и других злокачественных новообразований. Об этом также свидетельствуют данные онкологической заболеваемости фармацевтов и лабораторных работников с возможной профессиональной экспозицией к химиопрепаратам. В России необходимы контроль онкологической заболеваемости у медицинских работников и мониторинг загрязнения химиопрепаратами рабочей среды на постоянной основе, так как проецировать оценки, полученные в других странах, на производственные условия, имеющие место в отечественных онкологических учреждениях, неправомерно. Данные биологического и эпидемиологического мониторинга должны стать основой эффективной профилактики возможных рисков здоровью лиц, работающих с противоопухолевыми препаратами в нашей стране.

Об авторах

Л. Г. Соленова
НИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России.
Россия
115478 Москва, Каширское шоссе, 24.


М. Г. Якубовская
НИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России.
Россия
115478 Москва, Каширское шоссе, 24.


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Для цитирования:


Соленова Л.Г., Якубовская М.Г. Химиотерапия: возможные риски при обращении с противоопухолевыми препаратами. Успехи молекулярной онкологии. 2017;4(3):10-20. https://doi.org/10.17650/2313-805X-2017-4-3-10-20

For citation:


Solenova L.G., Yakubovskaya M.G. Chemotherapy: some potential risks under antineoplastic drugs handling. Advances in molecular oncology. 2017;4(3):10-20. (In Russ.) https://doi.org/10.17650/2313-805X-2017-4-3-10-20

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