Metabolic aspects of adoptive immunotherapy of tumors

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Abstract

In wide number of approaches to treatment of cancer immunotherapy plays special role. This approach exploits capabilities of immune system to support genetic constancy of different cells and tissues of the organism. Immunotherapy is designed to induce tumor cell destruction  by T-lymphocytes whose receptors can recognize peptides of mutant proteins complexed with the molecules of the major histocompatibility complex. In clinical practice T-lymphocytes can result in sustained and complete responses in patients whose cancers were resistant to available treatment options. Recent evidences suggest that efficiency of such therapy generally depends on metabolic properties of T-lymphocytes. A number of approaches allows modulate T-cell metabolism providing strategies to optimize activity of anti-tumor T-lymphocytes.

About the authors

D. B. Kazanskiy

Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Author for correspondence.
Email: kazansky1@yandex.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

Yu. Yu. Silaeva

Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

A. A. Kalinina

Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

M. A. Zamkova

Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

L. M. Khromykh

Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

N. A. Persiyantseva

Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

L. Kh. Dzholokhava

Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.

Email: fake@neicon.ru
24 Kashirskoe Shosse, Moscow 115478. Russian Federation

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