Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press10110.17650/2313-805X-2017-4-3-50-56REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИSecreted protein YB-1 and its prognostic significanceСекретируемый белок YB-1 и его прогностическая значимостьStavrovskayaA. A.СтавровскаяА. А.
Russian Federation

24 Kashirskoye Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

MoiseevaN. I.МоисееваН. И.
Russian Federation

24 Kashirskoye Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

Moiseeva@gmail.comGuensG. P.ГенсГ. П.
Russian Federation

Build. 1, 20 Delegatskaya St., Moscow 127473.

127473 Москва, ул. Делегатская, 20, стр 1.

RybalkinaE. Yu.РыбалкинаЕ. Ю.
Russian Federation

24 Kashirskoye Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.НИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России.A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia.ФГБОУ ВО «Московский медико-стоматологический университет им. А.И. Евдокимова» Минздрава России.150920174350561610201716102017Copyright ©; 2017, Stavrovskaya A.A., Moiseeva N.I., Guens G.P., Rybalkina E.Y.Copyright ©; 2017, Ставровская А.А., Моисеева Н.И., Генс Г.П., Рыбалкина Е.Ю.2017Stavrovskaya A.A., Moiseeva N.I., Guens G.P., Rybalkina E.Y.Ставровская А.А., Моисеева Н.И., Генс Г.П., Рыбалкина Е.Ю.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/101

The multifunctional protein YB-1 in prokaryotes and eukaryotes participates in various processes, among others performing the functions  of a regulator of transcription and translation of many genes. Intracellular localization and expression of YB-1 is an acknowledged prognostic marker for certain malignant tumors. However, it has recently become clear that YB-1 can be released from cells and present in body fluids, including inside vesicles. The review collected data on the secretion YB-1 (sYB-1) content in blood serum from patients with inflammatory diseases and various tumors. There is analyzed the influence of sYB-1 on normal and tumor cells. Data are presented that show that intracellular YB-1 and sYB-1 affect cells differently. The prognostic significance of sYB-1 and its form YB-1/p18 in malignant neoplasms is discussed.

Многофункциональный белок YB-1 (Y box-binding protein 1) в клетках прокариот и эукариот участвует в различных процессах, среди других выполняя функции регулятора транскрипции и трансляции многих генов. Внутриклеточная локализация и экспрессия YB-1 является признанным прогностическим маркером для некоторых злокачественных новообразований. Однако относительно недавно стало понятно, что YB-1 может выделятся из клеток и присутствует в жидкостях организма, в том числе находясь внутри везикул. В обзоре собраны данные относительно содержания секретируемого YB-1 (сYB-1) в сыворотке крови у больных с воспалительными заболеваниями и различными опухолями. Изучается влияние сYB-1 на нормальные и опухолевые клетки. Рассматриваются данные, показывающие, что внутриклеточный YB-1 и сYB-1 по-разному влияют на клетки. Обсуждается прогностическая значимость сYB-1 и его формы YB-1 / р18 при злокачественных новообразованиях.

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