Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press10210.17650/2313-805X-2017-4-3-57-66REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИPharmacogenetic testing of allelic variants of the CYP2D6 gene in hormone positive breast cancerФармакогенетическое тестирование аллельных вариантов гена CYP2D6 при гормоноположительном раке молочной железыLyubchenkoL. N.ЛюбченкоЛ. Н.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

clingen@mail.ruFilippovaM. G.ФилипповаМ. Г.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

ShendrikovaT. A.ШендриковаТ. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

ZhukovaL. G.ЖуковаЛ. Г.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

MekhtievaN. I.МехтиеваН. И.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

KrokhinaO. V.КрохинаО. В.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

PortnoyS. M.ПортнойС. М.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia.ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России.150920174357661610201716102017Copyright ©; 2017, Lyubchenko L.N., Filippova M.G., Shendrikova T.A., Zhukova L.G., Mekhtieva N.I., Krokhina O.V., Portnoy S.M.Copyright ©; 2017, Любченко Л.Н., Филиппова М.Г., Шендрикова Т.А., Жукова Л.Г., Мехтиева Н.И., Крохина О.В., Портной С.М.2017Lyubchenko L.N., Filippova M.G., Shendrikova T.A., Zhukova L.G., Mekhtieva N.I., Krokhina O.V., Portnoy S.M.Любченко Л.Н., Филиппова М.Г., Шендрикова Т.А., Жукова Л.Г., Мехтиева Н.И., Крохина О.В., Портной С.М.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/102

Tamoxifen is the drug of choice for endocrine therapy of hormone receptor- positive breast cancer in women in the reproductive period.  The metabolic activity of tamoxifen is determined by the activity of the enzyme CYP2D6, encoded by the gene of the same name: under  the action of the enzyme, tamoxifen passes into the metabolically active form, endoxyphene. Pharmacogenetic testing of the CYP2D6 gene  in patients with hormone-positive breast cancer can help predict the effectiveness of therapy and assess the risk of side effects with the aim  of improving long-term treatment outcomes.

Тамоксифен является препаратом выбора при эндокринотерапии гормоноположительного рака молочной железы у женщин в репродуктивном возрасте. Метаболическая активность тамоксифена в организме определяется активностью фермента CYP2D6, кодируемого одноименным геном: под действием фермента тамоксифен переходит в метаболически активную форму – эндоксифен. Фармакогенетическое тестирование гена CYP2D6 у пациентов с гормоноположительным раком молочной железы поможет прогнозировать эффективность терапии и оценить риск развития побочных эффектов в целях улучшения отдаленных результатов лечения.

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