Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press11410.17650/2313-805X-2017-4-4-17-23REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИCYCLOPHILIN A: STRUCTURE AND FUNCTIONSЦИКЛОФИЛИН А: СТРОЕНИЕ И ФУНКЦИИKalininaA. A.КалининаА. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

Анастасия Андреевна Калинина.

115478 Москва, Каширское шоссе, 24

aakalinina89@gmail.comKhromykhL. M.ХромыхЛ. М.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

KazanskyD. B.КазанскийД. Б.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России151220174417230212201702122017Copyright ©; 2017, Kalinina A.A., Khromykh L.M., Kazansky D.B.Copyright ©; 2017, Калинина А.А., Хромых Л.М., Казанский Д.Б.2017Kalinina A.A., Khromykh L.M., Kazansky D.B.Калинина А.А., Хромых Л.М., Казанский Д.Б.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/114

Cyclophilins belong to a large family of ancient conservative proteins with peptidyl-prolyl-cis-trans isomerase activity. The main member of this family – cyclophilin A – was discovered as an intracellular ligand for cyclosporine A. Further investigations revealed a wide range of functions of cyclophilin A. Cyclophilin A is involved in T-cell signaling, it takes part in folding, assembly and intracellular transport of proteins, as well as acts as an antioxidant. Different cell types secrete cyclophilin A under infection or oxidative stress. Cyclophilin A is one of the main factors involved in inflammation and pathogenesis of autoimmune, cardiovascular and other diseases. This protein is thought to take part in tumor progression. In this review we describe the structure of cyclophilin A and its main known functions in health and disease.

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