Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press1210.17650/2313-805X.2014.1.1.12-17REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИThe role of E-cadherin in neoplastic evolution of epithelial cellsРоль Е-кадхерина в неопластической эволюции эпителиальных клетокGloushankovaN. A.ГлушанковаН. А.
Russian Federation
natglu@hotmail.comZhitnyakI. Yu.ЖитнякИ. Ю.
Russian Federation
AyolloD. V.АйоллоД. В.
Russian Federation
RubtsovaS. N.РубцоваС. Н.
Russian Federation
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва150120141112170206201502062015Copyright ©; 2014, Gloushankova N.A., Zhitnyak I.Y., Ayollo D.V., Rubtsova S.N.Copyright ©; 2014, Глушанкова Н.А., Житняк И.Ю., Айолло Д.В., Рубцова С.Н.2014Gloushankova N.A., Zhitnyak I.Y., Ayollo D.V., Rubtsova S.N.Глушанкова Н.А., Житняк И.Ю., Айолло Д.В., Рубцова С.Н.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/12

Interaction of the extracellular domains of the transmembrane proteins cadherins provides cell-cell adhesion. For many years epithelial E- cadherin was regarded as a tumor suppressor and was used as a prognostic marker in cancer. Suppression of E-cadherin expression was observed in many carcinomas. During recent years, the tumor suppressor function of E-cadherin is being reconsidered. It has been shown that ductal breast carcinomas, colorectal carcinomas, oral cavity carcinomas, and squamous cell carcinomas of the head and neck can retain E-cadherin expression. Immunohistochemical staining with a panel of monoclonal antibodies revealed membrane localization of E-cadherin in many tumors. It was shown that transformed epithelial cells in vitro form dynamic adherens junctions that are essential for the effective collective migration of these cells.

Трансмембранные белки кадхерины обеспечивают межклеточную адгезию через взаимодействие внеклеточных доменов. На протяжении многих лет эпителиальный Е-кадхерин считался опухолевым супрессором и рассматривался в качестве прогностического маркера у онкологических больных. Угнетение экспрессии Е-кадхерина наблюдали во многих карциномах. В последние несколько лет пересматриваются представления о супрессирующей оли Е-кадхерина. Показано, что протоковые карциномы молочной железы, карциномы толстой кишки, карциномы полости рта, плоскоклеточные карциномы головы и шеи могут сохранять экспрессию Е-кадхерина. При иммуногистохимическом окрашивании с использованием панели моноклональных антител во многих опухолях была выявлена мембранная локализация Е-кадхерина. В трансформированных эпителиоцитах in vitro были обнаружены динамичные межклеточные адгезионные контакты, образованные Е-кадхерином, которые важны для эффективной коллективной миграции клеток.

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