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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Advances in Molecular Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Advances in Molecular Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Успехи молекулярной онкологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-805X</issn><issn publication-format="electronic">2413-3787</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">136</article-id><article-id pub-id-type="doi">10.17650/2313-805X-2018-5-1-53-59</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>EXPERIMENTAL RESEARCH</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">BRCA1 mRNA expression levels as an predictor of response to neoadjuvant chemotherapy in breast cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Экспрессия мРНК гена BRCA1 в опухолях молочной железы как предиктор ответа на неоадъювантную химиотерапию</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7419-4512</contrib-id><name-alternatives><name xml:lang="en"><surname>Tsyganov</surname><given-names>M. M.</given-names></name><name xml:lang="ru"><surname>Цыганов</surname><given-names>М. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>5 Kooperativnyy Lane, Tomsk 634009</p></bio><bio xml:lang="ru"><p>634009 Томск, пер. Кооперативный, 5</p></bio><email>TsyganovMM@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8815-2786</contrib-id><name-alternatives><name xml:lang="en"><surname>Ibragimova</surname><given-names>M. K.</given-names></name><name xml:lang="ru"><surname>Ибрагимова</surname><given-names>М. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>5 Kooperativnyy Lane, Tomsk 634009</p></bio><bio xml:lang="ru"><p>634009 Томск, пер. Кооперативный, 5</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9568-3371</contrib-id><name-alternatives><name xml:lang="en"><surname>Deryusheva</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Дерюшева</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>5 Kooperativnyy Lane, Tomsk 634009</p></bio><bio xml:lang="ru"><p>634009 Томск, пер. Кооперативный, 5</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2953-0350</contrib-id><name-alternatives><name xml:lang="en"><surname>Kazantseva</surname><given-names>P. V.</given-names></name><name xml:lang="ru"><surname>Казанцева</surname><given-names>П. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>5 Kooperativnyy Lane, Tomsk 634009</p></bio><bio xml:lang="ru"><p>634009 Томск, пер. Кооперативный, 5</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2917-8158</contrib-id><name-alternatives><name xml:lang="en"><surname>Garbukov</surname><given-names>E. Yu.</given-names></name><name xml:lang="ru"><surname>Гарбуков</surname><given-names>Е. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>5 Kooperativnyy Lane, Tomsk 634009</p></bio><bio xml:lang="ru"><p>634009 Томск, пер. Кооперативный, 5</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4382-5697</contrib-id><name-alternatives><name xml:lang="en"><surname>Slonimskaya</surname><given-names>E. M.</given-names></name><name xml:lang="ru"><surname>Слонимская</surname><given-names>Е. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>5 Kooperativnyy Lane, Tomsk 634009</p></bio><bio xml:lang="ru"><p>634009 Томск, пер. Кооперативный, 5</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0714-8927</contrib-id><name-alternatives><name xml:lang="en"><surname>Litviakov</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Литвяков</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>5 Kooperativnyy Lane, Tomsk 634009</p></bio><bio xml:lang="ru"><p>634009 Томск, пер. Кооперативный, 5</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский институт онкологии ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2018</year></pub-date><volume>5</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>53</fpage><lpage>59</lpage><history><date date-type="received" iso-8601-date="2018-05-14"><day>14</day><month>05</month><year>2018</year></date><date date-type="accepted" iso-8601-date="2018-05-14"><day>14</day><month>05</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Tsyganov M.M., Ibragimova M.K., Deryusheva I.V., Kazantseva P.V., Garbukov E.Y., Slonimskaya E.M., Litviakov N.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, Цыганов М.М., Ибрагимова М.К., Дерюшева И.В., Казанцева П.В., Гарбуков Е.Ю., Слонимская Е.М., Литвяков Н.В.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Tsyganov M.M., Ibragimova M.K., Deryusheva I.V., Kazantseva P.V., Garbukov E.Y., Slonimskaya E.M., Litviakov N.V.</copyright-holder><copyright-holder xml:lang="ru">Цыганов М.М., Ибрагимова М.К., Дерюшева И.В., Казанцева П.В., Гарбуков Е.Ю., Слонимская Е.М., Литвяков Н.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://umo.abvpress.ru/jour/article/view/136">https://umo.abvpress.ru/jour/article/view/136</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>genes expression</kwd><kwd>BRCA1</kwd><kwd>neoadjuvant chemotherapy</kwd><kwd>chemotherapy efficacy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>экспрессия генов</kwd><kwd>BRCA1</kwd><kwd>неоадъювантная химиотерапия</kwd><kwd>эффективность химиотерапии</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках конкурса 2018–2020 гг. на получение стипендии Президента РФ молодым ученым и аспирантам.</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Johnson N., Fletcher O., Palles C. et al. Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility. Hum Mol Genet 2007;16(9):1051–7. DOI: 10.1093/hmg/ddm050. PMID: 17341484.</mixed-citation><mixed-citation xml:lang="ru">Johnson N., Fletcher O., Palles C. et al. Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility. Hum Mol Genet 2007;16(9):1051–7. DOI: 10.1093/hmg/ddm050. PMID: 17341484.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Kadouri L., Hubert A., Rotenberg Y. et al. Cancer risks in carriers of the BRCA1/2 Ashkenazi founder mutations. J Med Genet 2007;44(7):467–71. DOI: 10.1136/jmg.2006.048173. PMID: 17307836.</mixed-citation><mixed-citation xml:lang="ru">Kadouri L., Hubert A., Rotenberg Y. et al. Cancer risks in carriers of the BRCA1/2 Ashkenazi founder mutations. J Med Genet 2007;44(7):467–71. DOI: 10.1136/jmg.2006.048173. PMID: 17307836.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Simard J., Tonin P., Durocher F. et al. Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families. Nat Genet 1994;8(4):392–8. DOI: 10.1038/ng1294-392. PMID: 7894492.</mixed-citation><mixed-citation xml:lang="ru">Simard J., Tonin P., Durocher F. et al. Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families. Nat Genet 1994;8(4):392–8. DOI: 10.1038/ng1294-392. PMID: 7894492.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Palmero E.I., Alemar B., Schüler-Faccini L. et al. Screening for germline BRCA1, BRCA2, TP53 and CHEK2 mutations in families at-risk for hereditary breast cancer identified in a population-based study from Southern Brazil. Genet Mol Biol 2016;39(2):210–22. DOI: 10.1590/ 1678-4685-GMB-2014-0363. PMID: 27223485.</mixed-citation><mixed-citation xml:lang="ru">Palmero E.I., Alemar B., Schüler-Faccini L. et al. Screening for germline BRCA1, BRCA2, TP53 and CHEK2 mutations in families at-risk for hereditary breast cancer identified in a population-based study from Southern Brazil. Genet Mol Biol 2016;39(2):210–22. DOI: 10.1590/ 1678-4685-GMB-2014-0363. PMID: 27223485.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Byrski T., Huzarski T., Dent R. et al. Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res Treat 2014;147(2):401–5. DOI: 10.1007/s10549-014-3100-x. PMID: 25129345.</mixed-citation><mixed-citation xml:lang="ru">Byrski T., Huzarski T., Dent R. et al. Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res Treat 2014;147(2):401–5. DOI: 10.1007/s10549-014-3100-x. PMID: 25129345.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Byrski T., Gronwald J., Huzarski T. et al. Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. J Clin Oncol 2010;28(3):375–9. DOI: 10.1200/JCO.2008.20.7019. PMID: 20008645.</mixed-citation><mixed-citation xml:lang="ru">Byrski T., Gronwald J., Huzarski T. et al. Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. J Clin Oncol 2010;28(3):375–9. DOI: 10.1200/JCO.2008.20.7019. PMID: 20008645.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Гафтон И.Г., Имянитов Е.Н., Семиглазов В.В. и др. Экспрессия гена BRCA1 при нейроэндокринных опухолях желудочно-кишечного тракта. Сибирский онкологический журнал 2014;16(4):11–5. [Gafton I.G., Imyanitov E.N., Semiglazov V.V. et al. BRCA1 gene expression in endocrine tumors of the gastrointestinal tract. Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology 2014;16(4):11–5. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Гафтон И.Г., Имянитов Е.Н., Семиглазов В.В. и др. Экспрессия гена BRCA1 при нейроэндокринных опухолях желудочно-кишечного тракта. Сибирский онкологический журнал 2014;16(4):11–5. [Gafton I.G., Imyanitov E.N., Semiglazov V.V. et al. BRCA1 gene expression in endocrine tumors of the gastrointestinal tract. Sibirskiy onkologicheskiy zhurnal = Siberian Journal of Oncology 2014;16(4):11–5. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Imyanitov E.N., Moiseyenko V.M. Drug therapy for hereditary cancers. Hered Cancer Clin Pract 2011;9(1):5. DOI: 10.1186/1897-4287-9-5. PMID: 21819606.</mixed-citation><mixed-citation xml:lang="ru">Imyanitov E.N., Moiseyenko V.M. Drug therapy for hereditary cancers. Hered Cancer Clin Pract 2011;9(1):5. DOI: 10.1186/1897-4287-9-5. PMID: 21819606.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Schwartz G.F., Hortobagyi G.N. Proceedings of the consensus conference on neoadjuvant chemotherapy in carcinoma of the breast, April 26–28, 2003, Philadelphia, Pennsylvania. Breast J 2004;10(4):273–94.</mixed-citation><mixed-citation xml:lang="ru">Schwartz G.F., Hortobagyi G.N. Proceedings of the consensus conference on neoadjuvant chemotherapy in carcinoma of the breast, April 26–28, 2003, Philadelphia, Pennsylvania. Breast J 2004;10(4):273–94.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29(9):e45. PMID: 11328886.</mixed-citation><mixed-citation xml:lang="ru">Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29(9):e45. PMID: 11328886.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Kurebayashi J., Yamamoto Y., Kurosumi M. et al. Loss of BRCA1 expression may predict shorter time-toprogression in metastatic breast cancer patients treated with taxanes. Anticancer Res 2006;26(1):695–701. PMID: 16739340.</mixed-citation><mixed-citation xml:lang="ru">Kurebayashi J., Yamamoto Y., Kurosumi M. et al. Loss of BRCA1 expression may predict shorter time-toprogression in metastatic breast cancer patients treated with taxanes. Anticancer Res 2006;26(1):695–701. PMID: 16739340.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Mahmoud A.M., Macias V., Al-Alem U. et al. BRCA1 protein expression and subcellular localization in primary breast cancer: automated digital microscopy analysis of tissue microarrays. PLoS One 2017;12(9):e0184385. DOI: 10.1371/journal.pone.0184385. PMID: 28863181.</mixed-citation><mixed-citation xml:lang="ru">Mahmoud A.M., Macias V., Al-Alem U. et al. BRCA1 protein expression and subcellular localization in primary breast cancer: automated digital microscopy analysis of tissue microarrays. PLoS One 2017;12(9):e0184385. DOI: 10.1371/journal.pone.0184385. PMID: 28863181.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Egawa C., Motomura K., Miyoshi Y. et al. Increased expression of BRCA1 mRNA predicts favorable response to anthracycline-containing chemotherapy in breast cancers. Breast Cancer Res Treat 2003;78(1):45–50. PMID: 12611456.</mixed-citation><mixed-citation xml:lang="ru">Egawa C., Motomura K., Miyoshi Y. et al. Increased expression of BRCA1 mRNA predicts favorable response to anthracycline-containing chemotherapy in breast cancers. Breast Cancer Res Treat 2003;78(1):45–50. PMID: 12611456.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Lafarge S., Sylvain V., Ferrara M., Bignon Y.J. Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway. Oncogene 2001;20(45):6597–606. DOI: 10.1038/sj.onc.1204812. PMID: 11641785.</mixed-citation><mixed-citation xml:lang="ru">Lafarge S., Sylvain V., Ferrara M., Bignon Y.J. Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway. Oncogene 2001;20(45):6597–606. DOI: 10.1038/sj.onc.1204812. PMID: 11641785.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Mullan P.B., Quinn J.E., Gilmore P.M. et al. BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents. Oncogene 2001;20(43):6123–31. DOI: 10.1038/sj.onc.1204712. PMID: 11593420.</mixed-citation><mixed-citation xml:lang="ru">Mullan P.B., Quinn J.E., Gilmore P.M. et al. BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents. Oncogene 2001;20(43):6123–31. DOI: 10.1038/sj.onc.1204712. PMID: 11593420.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Quinn J.E., Kennedy R.D., Mullan P.B. et al. BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. Cancer Res 2003;63(19):6221–8. PMID: 14559807.</mixed-citation><mixed-citation xml:lang="ru">Quinn J.E., Kennedy R.D., Mullan P.B. et al. BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. Cancer Res 2003;63(19):6221–8. PMID: 14559807.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Harte M.T., Gorski J.J., Savage K.I. et al. NF-κB is a critical mediator of BRCA1- induced chemoresistance. Oncogene 2014;33(1):713–23. DOI: 10.1038/ onc.2013.10. PMID: 23435429.</mixed-citation><mixed-citation xml:lang="ru">Harte M.T., Gorski J.J., Savage K.I. et al. NF-κB is a critical mediator of BRCA1- induced chemoresistance. Oncogene 2014;33(1):713–23. DOI: 10.1038/ onc.2013.10. PMID: 23435429.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Sau A., Lau R., Cabrita M.A. et al. Persistent activation of NF-κB in BRCA1-deficient mammary progenitors drives aberrant proliferation and accumulation of DNA damage. Cell Stem Cell 2016;19(1):52–65. DOI: 10.1016/j.stem.2016.05.003. PMID: 27292187.</mixed-citation><mixed-citation xml:lang="ru">Sau A., Lau R., Cabrita M.A. et al. Persistent activation of NF-κB in BRCA1-deficient mammary progenitors drives aberrant proliferation and accumulation of DNA damage. Cell Stem Cell 2016;19(1):52–65. DOI: 10.1016/j.stem.2016.05.003. PMID: 27292187.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
