Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press1410.17650/2313-805X.2014.1.1.27-35REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИGrowth factors, their receptors and down-stream signaling proteins in human tumors: from experiment to clinical practiceФакторы роста, их рецепторы и нижележащие сигнальные белки: от эксперимента к клиникеGershteinE. S.ГерштейнЕ. С.
Russian Federation
esgershtein@gmail.comKushlinskyN. E.КушлинскийН. Е.
Russian Federation
ФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва150120141127350206201502062015Copyright ©; 2014, Gershtein E.S., Kushlinsky N.E.Copyright ©; 2014, Герштейн Е.С., Кушлинский Н.Е.2014Gershtein E.S., Kushlinsky N.E.Герштейн Е.С., Кушлинский Н.Е.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/14

The basic contemporary data and the results of authors’ long-term personal research devoted to the role of auto / paracrine growth factors, their receptors and some down-stream signaling proteins (PI3K, Akt, NF-κB) in clinical course, prognosis and development of hormonal and drug sensitivity of various human tumors are reviewed. The data on the key targeted drugs suppressing various growth factor signaling pathways components are summarized with special attention to the criteria of assessment of individual sensitivity to these drugs including those based on modern molecular biologic technologies.

В обзоре представлены основополагающие данные современной литературы и результаты собственных многолетних исследований роли ауто / паракринных факторов роста, их рецепторов и некоторых нижележащих сигнальных белков (PI3K, Akt, NF-κB) в клиническом течении, прогнозе и формировании гормональной и / или лекарственной чувствительности различных опухолей человека. Суммированы также данные о ключевых таргетных препаратах, направленных на подавление различных компонентов сигнальных путей факторов роста; критериях оценки индивидуальной чувствительности к этим препаратам, в том числе с использованием современных молекулярно-биологических технологий.

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