Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press14210.17650/2313-805X-2018-5-2-8-15REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИA STUDY OF THE ROLE OF MICRORNA IN PITUITARY ADENOMAИЗУЧЕНИЕ РОЛИ МИКРОРНК ПРИ АДЕНОМЕ ГИПОФИЗАhttps://orcid.org/0000-0002-4965-0835GareevI. F.ГареевИ. Ф.
Russian Federation

3 Lenina St., Ufa 450008, Bashkortostan Republic

Ильгиз Фанилевич Гареев

Республика Башкортостан, Уфа 450008, ул. Ленина, 3

ilgiz_gareev@mail.ruhttps://orcid.org/0000-0002-6149-5460BeylerliO. A.БейлерлиО. А.
Russian Federation

3 Lenina St., Ufa 450008, Bashkortostan Republic

Республика Башкортостан, Уфа 450008, ул. Ленина, 3

Bashkortostan State Medical University, Ministry of Health of RussiaФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России15052018528151807201818072018Copyright ©; 2018, Gareev I.F., Beylerli O.A.Copyright ©; 2018, Гареев И.Ф., Бейлерли О.А.2018Gareev I.F., Beylerli O.A.Гареев И.Ф., Бейлерли О.А.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/142

MicroRNAs are a new class of small non-coding RNAs, a length of 18–22 nucleotides that play a decisive role as posttranscriptional regulators of gene expression. Due to the large number of genes, regulated microRNAs, microRNAs are involved in many cellular processes. The study of the impairment of the expression of the target genes of microRNA, often associated with changes in important biological characteristics, provides a significant understanding of the role of microRNAs in oncogenesis. New evidence suggests that aberrant microRNA expression or dysregulation of endogenous microRNAs affects the onset and development of tumors, including adenomas of the pituitary gland. In this review, the significance of some microRNAs in the pathology of the pituitary adenoma will be assessed, as well as data on the study of microRNAs as therapeutic targets and new biomarkers.

МикроРНК представляют собой новый класс малых некодирующих РНК длиной 18–22 нуклеотида, которые играют решающую роль в качестве посттранскрипционных регуляторов экспрессии генов. Из-за большого количества регулируемых генов микроРНК участвуют во многих клеточных процессах. Исследование нарушений экспрессии генов-мишеней микроРНК, часто связанных с изменениями важных биологических характеристик, дает представление о роли микроРНК в онкогенезе. Новые данные свидетельствуют о том, что аберрантная экспрессия микроРНК или дисрегуляция эндогенных микроРНК влияет на возникновение и развитие опухолей, в том числе аденом гипофиза. В настоящем обзоре оценена значимость некоторых микроРНК в патологии аденомы гипофиза, а также представлены данные, касающиеся изучения микроРНК в качестве терапевтических мишеней и новых биомаркеров.

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