Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press14510.17650/2313-805X-2018-5-2-31-41RESEARCH ARTICLESЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИTHE INFLUENCE OF PROPIONATE ON THE SPECTRUM OF LONG-CHAIN FATTY ACIDS IN CERVICAL CELLS DURING DIS- AND NEOPLASTIC TRANSFORMATIONВЛИЯНИЕ ПРОПИОНАТА НА СПЕКТР ВЫСШИХ ЖИРНЫХ КИСЛОТ В КЛЕТКАХ ШЕЙКИ МАТКИ ПРИ ДИС- И НЕОПЛАСТИЧЕСКОЙ ТРАНСФОРМАЦИИhttps://orcid.org/0000-0001-5231-9273KayukovaE. V.КаюковаЕ. В.
Russian Federation

39A Gor’kogo St., Chita 672000

Елена Владимировна Каюкова.

672000 Чита, ул. Горького, 39Аelena_pochta22@mail.ruhttps://orcid.org/0000-0002-5447-4223BelokrinitskayaT. E.БелокринцкаяТ. Е.
Russian Federation

39A Gor’kogo St., Chita 672000

672000 Чита, ул. Горького, 39А

https://orcid.org/0000-0002-8601-3499TereshkovP. P.ТерешковП. П.
Russian Federation

39A Gor’kogo St., Chita 672000

672000 Чита, ул. Горького, 39А

Chita State Academy of Medicine, Ministry of Health of RussiaФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России150520185231411807201818072018Copyright ©; 2018, Kayukova E.V., Belokrinitskaya T.E., Tereshkov P.P.Copyright ©; 2018, Каюкова Е.В., Белокринцкая Т.Е., Терешков П.П.2018Kayukova E.V., Belokrinitskaya T.E., Tereshkov P.P.Каюкова Е.В., Белокринцкая Т.Е., Терешков П.П.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/145

Background. Metabolic reprogramming of tumor cells is one of the leading links in carcinogenesis. The objective to confirm the hypothesis of a propionate pathway for the synthesis of long-chain acids with an odd number of carbon atoms in cervical cancer.

Materials and methods. As samples for the study were biopsies of the colli uteri, from which a suspension of tumor cells was obtained (20 – cervical cancer, 20 – cervical intraepithelial neoplasia III grade, 18 – endocervical scraping from healthy women). The spectrum of fatty acids (FA) was analyzed before, after 24 hours incubation without and with 50 μmol/l propionic acid by the gas chromatography method.

Results. Metabolism of FA is multidirectional in different locus in cervical cancer. In the locus of cervical cancer, most likely, there is a propionic pathway for the synthesis of FA using palmitate. In cervical intraepithelial neoplasia III grade, the metabolism of FA is another. Palmitic acid was used for synthesis stearate, which was metabolized to oleic acid.

Сonclusion. The specificity of biochemical changes within one organ and one pathology has been revealed, which reflects the stage-by-stage development of the oncological process.

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