Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press1510.17650/2313-805X.2014.1.1.36-47REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИInfluence of genetic polymorphism of oncogenic viruses on the risk of human tumors and their specific preventionВлияние полиморфизма геномов онкогенных вирусов на риск возникновения опухолей человека и их специфическая профилактикаGurtsevichV. E.ГурцевичВ. Э.
Russian Federation
gurvlad532@yahoo.comSenyutaN. B.СенютаН. Б.
Russian Federation
SmirnovaK. V.СмирноваК. В.
Russian Federation
Federal State Budgetary Institution “N. N. Blokhin Russian Cancer Research Center“, Russian Academy of Medical Sciences, MoscowФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва150120141136470206201502062015Copyright ©; 2014, Gurtsevich V.E., Senyuta N.B., Smirnova K.V.Copyright ©; 2014, Гурцевич В.Э., Сенюта Н.Б., Смирнова К.В.2014Gurtsevich V.E., Senyuta N.B., Smirnova K.V.Гурцевич В.Э., Сенюта Н.Б., Смирнова К.В.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/15

Numerous studies have shown that approximately 20 % of all human tumors are neoplasms of an infectious nature. This review is an attempt to summarize the current understanding of the role of known human oncogenic viruses and their genetic variants on the risk of the human cancers development, as well as to show the existing measures of specific prevention of virus-induced tumors. It was paid also attention to the interaction between viral and cellular proteins, including tumor suppressors, and to the evaluation the significance of this interaction for specific oncogenic viruses and virus-associated tumors.

Многочисленными исследованиями доказано, что примерно 20 % всех опухолей человека являются новообразованиями инфекционной природы. Данный обзор представляет собой попытку суммировать современные представления о роли известных онкогенных вирусов и их генетических вариантов в риске возникновения опухолей человека, а также показать существующие меры специфической профилактики вирус-индуцированных опухолей. Уделено также внимание вопросам взаимодействия между вирусными белками и клеточными белками, включая опухолевые супрессоры, и оценена значимость такого взаимодействия для конкретных опухолеродных вирусов и ассоциированных с ними опухолей.

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