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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Advances in Molecular Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Advances in Molecular Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Успехи молекулярной онкологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-805X</issn><issn publication-format="electronic">2413-3787</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">164</article-id><article-id pub-id-type="doi">10.17650/2313-805X-2018-5-3-40-50</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>RESEARCH ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Relation of EGFR/PI3K/AKT signaling components with tamoxifen efficacy in patients with estrogen-dependent breast cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Взаимосвязь компонентов EGFR/PI3K/Akt-сигнального пути с эффективностью терапии тамоксифеном у больных эстрогензависимым раком молочной железы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3009-2404</contrib-id><name-alternatives><name xml:lang="en"><surname>Dronova</surname><given-names>T. A.</given-names></name><name xml:lang="ru"><surname>Дронова</surname><given-names>Т. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>tanyadronova@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0562-3878</contrib-id><name-alternatives><name xml:lang="en"><surname>Babyshkina</surname><given-names>N. N.</given-names></name><name xml:lang="ru"><surname>Бабышкина</surname><given-names>Н. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9429-9813</contrib-id><name-alternatives><name xml:lang="en"><surname>Zavyalova</surname><given-names>M. V.</given-names></name><name xml:lang="ru"><surname>Завьялова</surname><given-names>М. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9468-1980</contrib-id><name-alternatives><name xml:lang="en"><surname>Patalyak</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Паталяк</surname><given-names>С. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4382-5697</contrib-id><name-alternatives><name xml:lang="en"><surname>Slonimskaya</surname><given-names>E. M.</given-names></name><name xml:lang="ru"><surname>Слонимская</surname><given-names>Е. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1526-9013</contrib-id><name-alternatives><name xml:lang="en"><surname>Cherdyntseva</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Чердынцева</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0898-3075</contrib-id><name-alternatives><name xml:lang="en"><surname>Kzhyshkowska</surname><given-names>J. G.</given-names></name><name xml:lang="ru"><surname>Кжышковска</surname><given-names>Ю. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff5"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Саncеr Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский институт онкологииФГБНУ «Томский национальный исследовательский медицинский центр РАН</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">National Research Tomsk State University</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Национальный исследовательский Томский государственный университет»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Siberian State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">University of Heidelberg, Mannheim, Germany</institution></aff><aff><institution xml:lang="ru">Университет Гейдельберга</institution></aff></aff-alternatives><aff id="aff5"><institution>Германия, Маннхайм</institution></aff><pub-date date-type="pub" iso-8601-date="2018-09-15" publication-format="electronic"><day>15</day><month>09</month><year>2018</year></pub-date><volume>5</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>40</fpage><lpage>50</lpage><history><date date-type="received" iso-8601-date="2018-11-10"><day>10</day><month>11</month><year>2018</year></date><date date-type="accepted" iso-8601-date="2018-11-10"><day>10</day><month>11</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Dronova T.A., Babyshkina N.N., Zavyalova M.V., Patalyak S.V., Slonimskaya E.M., Cherdyntseva N.V., Kzhyshkowska J.G.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, Дронова Т.А., Бабышкина Н.Н., Завьялова М.В., Паталяк С.В., Слонимская Е.М., Чердынцева Н.В., Кжышковска Ю.Г.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Dronova T.A., Babyshkina N.N., Zavyalova M.V., Patalyak S.V., Slonimskaya E.M., Cherdyntseva N.V., Kzhyshkowska J.G.</copyright-holder><copyright-holder xml:lang="ru">Дронова Т.А., Бабышкина Н.Н., Завьялова М.В., Паталяк С.В., Слонимская Е.М., Чердынцева Н.В., Кжышковска Ю.Г.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://umo.abvpress.ru/jour/article/view/164">https://umo.abvpress.ru/jour/article/view/164</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>estrogen-dependent breast cancer</kwd><kwd>tamoxifen</kwd><kwd>EGFR/PI3K/AKT signaling</kwd><kwd>gene polymorphism</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>эстрогензависимый рак молочной железы</kwd><kwd>тамоксифен</kwd><kwd>EGFR/PI3K/Akt-сигнальный каскад</kwd><kwd>полиморфизм генов</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена при финансовой поддержке Гранта РФФИ № 17-29-06037 офи_м «Геномные механизмы регуляции опухолевой прогрессии рака молочной железы в условиях лекарственной терапии».</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. 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