Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press1710.17650/2313-805X.2014.1.1.56-68REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИMechanisms of carcinogenesis prevention by flavonoidsМеханизмы антиканцерогенного действия флавоноидовBelitskyG. A.БелицкийГ. А.
Russian Federation
KirsanovK. I.КирсановК. И.
Russian Federation
LesovayaE. A.ЛесоваяЕ. А.
Russian Federation
YakubovskayaM. G.ЯкубовскаяМ. Г.
Russian Federation
mgyakubovskaya@mail.ruFederal State Budgetary Institution “N. N. Blokhin Russiаn Cancer Research Center”, Russian Academy of Medical Sciences, MoscowФГБУ «РОНЦ им. Н. Н. Блохина» РАМН, Москва150120141156680206201502062015Copyright ©; 2014, Belitsky G.A., Kirsanov K.I., Lesovaya E.A., Yakubovskaya M.G.Copyright ©; 2014, Белицкий Г.А., Кирсанов К.И., Лесовая Е.А., Якубовская М.Г.2014Belitsky G.A., Kirsanov K.I., Lesovaya E.A., Yakubovskaya M.G.Белицкий Г.А., Кирсанов К.И., Лесовая Е.А., Якубовская М.Г.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/17

The mechanisms of anticancerogenic effects of flavanoids and isocyanates from the plants widely consumed in the midland belt of Russia were reviewed. Data of studies both in vitro and in vivo were analyzed. Special attention was paid to inhibition of targets responsible for carcinogen metabolic activation, carcinogenesis promotion and tumor progression as well as neoangiogenesis. Besides that the antioxidant properties of flavonoids and their effects on cell cycle regulation, apoptosis initiation and cell mobility were considered.

Целью представленного обзора является анализ механизмов антиканцерогенного действия флавоноидов и изоцианатов на примере ряда соединений, широко употребляемых в средней полосе. В обзоре приведены данные исследований антиканцерогенного действия этих соединений в экспериментах in vitro и in vivo, рассмотрены мишени ингибирования действия химических канцерогенов в цепи их метаболизма, антиоксидантные эффекты флавоноидов, влияние пищевых полифенолов на метаболизм канцерогенных соединений, процессы промоции канцерогенеза и прогрессии опухоли, регуляцию клеточного цикла, цитоскелет и подвижность трансформированных клеток, индукцию апоптоза и неоангиогенез.

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