Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press17010.17650/2313-805X-2018-5-4-8-19REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИPotential of the use of methylation biomarkers for diagnostics and prognosis of hepatocellular carcinoma in liquid biopsyПотенциал использования биомаркеров метилирования для диагностики и прогноза гепатоцеллюлярной карциномы методом жидкостной биопсииhttps://orcid.org/0000-0001-6480-0793KustovaI. F.КустоваИ. Ф.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

Инна Феликсовна Кустова.

115478 Москва, Каширское шоссе, 24

innaku74@gmail.comhttps://orcid.org/0000-0002-9711-9256MakarovaA. S.МакароваА. С.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0001-9560-1383LazarevichN. L.ЛазаревичН. Л.
Russian Federation

Biological Faculty M.V. Lomonosov MSU.

24 Kashirskoe Shosse, Moscow 115478; Build. 12, 1 Leninskie Gory, Moscow 119234

Биологический факультет МГУ им. М.В. Ломоносова.

115478 Москва, Каширское шоссе, 24; 119234 Москва, Ленинские горы, 1, стр. 12

Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaНИИ канцерогенеза, ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииBiological Faculty, M.V. Lomonosov Moscow State UniversityФГБОУ ВО Московский государственный университет им. М.В. Ломоносова15122018548190301201903012019Copyright ©; 2018, Kustova I.F., Makarova A.S., Lazarevich N.L.Copyright ©; 2018, Кустова И.Ф., Макарова А.С., Лазаревич Н.Л.2018Kustova I.F., Makarova A.S., Lazarevich N.L.Кустова И.Ф., Макарова А.С., Лазаревич Н.Л.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/170

Hepatocellular carcinoma (HCC) is one of the most common types of liver cancer that is mainly diagnosed at advanced stages. Since molecular markers that are currently used in clinical practice are not sensitive enough for effective diagnosis of HCC, active search of new biomarkers is underway. Usе of minimally invasive liquid biopsy allows to detect specific markers of tumor growth and particularly alterations  of gene methylation patterns in cell-free DNA distinctive for HCC, in biological liquids of patients. In the present review the most promising diagnostic and prognostic methylation biomarkers that were detected in cell-free DNA of HCC patients are being considered.

Гепатоцеллюлярная карцинома (ГК) – самый распространенный тип рака печени, диагностируемый в основном на поздних стадиях. Применяемые в настоящее время в клинической практике молекулярные маркеры этого заболевания имеют недостаточную чувствительность для эффективной диагностики ГК, в связи с чем ведется активный поиск новых биомаркеров. Использование малоинвазивного метода жидкостной биопсии позволяет детектировать в биологических жидкостях пациентов специфические маркеры опухолевого роста, в частности характерное для ГК нарушение паттерна метилирования генов в ДНК, циркулирующей в крови. В настоящем обзоре рассмотрены наиболее перспективные для диагностики и прогноза биомаркеры метилирования, определяемые в циркулирующей ДНК крови пациентов с ГК.

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