Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press17210.17650/2313-805X-2018-5-4-30-40REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИProducing and prospects for the use of bispecific antibodies for the treatment of cancerCпособы получения и перспективы применения биспецифичных антител для лечения онкологических заболеванийhttps://orcid.org/0000-0003-0882-8171SedykhS. E.СедыхС. Е.
Russian Federation

8 Akademika Lavrentieva Prospekt, Novosibirsk 630090; 2 Pirogova St., Novosibirsk 630090

Сергей Евгеньевич Седых.

630090 Новосибирск, пр-т Академика Лаврентьева, 8; 630090 Новосибирск, ул. Пирогова, 2

sedyh@niboch.nsc.ruhttps://orcid.org/0000-0002-4988-8923NevinskyG. A.НевинскийГ. А.
Russian Federation

8 Akademika Lavrentieva Prospekt, Novosibirsk 630090; 2 Pirogova St., Novosibirsk 630090

630090 Новосибирск, пр-т Академика Лаврентьева, 8; 630090 Новосибирск, ул. Пирогова, 2

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of SciencesФГБУН Институт химической биологии и фундаментальной медицины, Сибирское отделение РАНNovosibirsk National State Research UniversityФГБОУ ВО Новосибирский национальный исследовательский государственный университет151220185430400301201903012019Copyright ©; 2018, Sedykh S.E., Nevinsky G.A.Copyright ©; 2018, Седых С.Е., Невинский Г.А.2018Sedykh S.E., Nevinsky G.A.Седых С.Е., Невинский Г.А.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/172

Bispecific antibody molecules contain two different antigen-binding centers. Particular interest in bispecific antibodies is due to their therapeutic application. Two preparations of therapeutic bispecific immunoglobulins, approved for use in the US and European countries, are aimed at the treatment of cancer. Studies published in recent years are devoted to various methods of obtaining monoclonal bispecific antibodies, to study their physicochemical properties, biological activity, preclinical and clinical trials. This paper reviews different approaches  to the production of antitumor bispecific immunoglobulins, as well as the prospects for their practical application.

Биспецифичными называют молекулы антител, содержащие 2 разных антигенсвязывающих центра. Особый интерес к молекулам биспецифичных антител обусловлен их терапевтическим применением. Два препарата терапевтических биспецифичных иммуноглобулинов, разрешенные к применению в США и странах Европы, направлены на лечение онкологических заболеваний. Работы, опубликованные в последние годы, посвящены различным способам получения моноклональных биспецифичных антител, исследованию их физико-химических свойств, биологической активности, доклиническим и клиническим испытаниям. Настоящий обзор рассматривает различные подходы к получению противоопухолевых биспецифичных иммуноглобулинов, а также перспективы их практического применения.

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