Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press17310.17650/2313-805X-2018-5-4-41-63REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИInfluence of DNA-binding compounds with cancer preventive activity on the mechanisms of gene expression regulationВлияние ДНК-тропных антиканцерогенных соединений на механизмы регуляции экспрессии геновhttps://orcid.org/0000-0002-8599-6833KirsanovK. I.КирсановК. И.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478; 6 Miklukho-Maklay St., Moscow 117198

Кирилл Игоревич Кирсанов.

115478 Москва, Каширское шоссе, 24; 117198 Москва, ул. Миклухо-Маклая, 6

kkirsanov85@yandex.ruVlasovaO. A.ВласоваО. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

FetisovT. I.ФетисовТ. И.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

ZenkovR. G.ЗенковР. Г.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-1967-9637LesovayaE. A.ЛесоваяЕ. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478; 9, Vysokovol’tnaya St., 390026 Ryazan

115478 Москва, Каширское шоссе, 24; 390026 Рязань, ул. Высоковольтная, 9

BelitskyG. A.БелицкийГ. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0001-9189-0712GurovaK.ГуроваК.
United States

Buffalo, NY

Штат Нью Йорк

https://orcid.org/0000-0002-9710-8178YakubovskayaM. G.ЯкубовскаяМ. Г.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииPeoples’ Friendship University of RussiaФГАОУ ВО Российский университет дружбы народовI.P. Pavlov Ryazan State Medical UniversityФГБОУ ВО «Рязанский государственный медицинский университет им. И.П. Павлова» Минздрава РоссииRoswell Park Cancer InstituteОнкологический центр Розвел Парк151220185441630301201903012019Copyright ©; 2018, Kirsanov K.I., Vlasova O.A., Fetisov T.I., Zenkov R.G., Lesovaya E.A., Belitsky G.A., Gurova K., Yakubovskaya M.G.Copyright ©; 2018, Кирсанов К.И., Власова О.А., Фетисов Т.И., Зенков Р.Г., Лесовая Е.А., Белицкий Г.А., Гурова К., Якубовская М.Г.2018Kirsanov K.I., Vlasova O.A., Fetisov T.I., Zenkov R.G., Lesovaya E.A., Belitsky G.A., Gurova K., Yakubovskaya M.G.Кирсанов К.И., Власова О.А., Фетисов Т.И., Зенков Р.Г., Лесовая Е.А., Белицкий Г.А., Гурова К., Якубовская М.Г.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/173

The presented review is devoted to the analysis of molecular mechanisms of action for different natural DNA-tropic compounds with established tumor preventive activity. Here we present their cancer preventive effects observed in vivo, mechanisms of DNA binding, influence on epigenetic regulation and “housekeeping” protein function. Additionally, the influence of these compounds on DNA helix parameters is discussed that should impact on epigenetic regulation of gene expression and formation of topologically associated domains.

Обзор посвящен анализу молекулярных механизмов действия ряда природных ДНК-тропных соединений с установленной антиканцерогенной активностью. Приведены данные исследований антиканцерогенного действия этих соединений в экспериментах in vivo, рассмотрены механизмы их связывания с ДНК, влияния на метилирование ДНК и модификацию гистонов, способность к ингибированию функций ферментов «домашнего хозяйства». Кроме того, проанализированы возможные эффекты этих соединений на характеристики дуплекса ДНК, что должно иметь значение для эпигенетической регуляции экспрессии генов и формирования топологически ассоциированных доменов.

DNA-tropic secondary plant metabolitescancer preventive activity of natural small moleculesDNA intercalationepigenetic regulation of gene expressionchromatin destabilizationДНК-тропные вторичные метаболиты растенийантиканцерогенное действие природных низкомолекулярных соединенийинтеркаляция ДНКэпигенетическая регуляция экспрессии геновдестабилизация хроматинаRussian Science Foundation, grant 17-15-01526Российский научный фонд, грант 17-15-01526Wiseman M.J. Nutrition and cancer: prevention and survival. Br J Nutr 2018:1—7. DOI: 10.1017/S0007114518002222. PMID: 30213279.Korkina L., Kostyuk V. Biotechnologically produced secondary plant metabolites for cancer treatment and prevention. Curr Pharm Biotechnol 2012;13(1):265—75. PMID: 21466424.Delgoda R., Murray J.E. Evolutionary perspectives on the role of plant secondary metabolites. In: Pharmacognosy: Fundamentals, Applications and Strategies. 1st ed. Oxoford, UK: Academic Press, 2017. P. 93—100. 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