Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press17410.17650/2313-805X-2018-5-4-64-71REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИHIFα as a target for different oncoproteins during carcinogenesisHIFα как объект воздействия различных онкобелков при канцерогенезеKobliakovV. A.КобляковВ. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

Валерий Александрович Кобляков.

115478 Москва, Каширское шоссе, 24

kobliakov@rambler.ruResearch Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaНИИ канцерогенеза ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России151220185464710301201903012019Copyright ©; 2018, Kobliakov V.A.Copyright ©; 2018, Кобляков В.А.2018Kobliakov V.A.Кобляков В.А.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/174

The basic characteristics of tumours are ability for invasiveness and metastasis. These properties are realized due to destruction of intercellular matrix caused with acidification of intercellular area stimulated with transition from tissue respiration to glycolysis. The transition  to glycolysis in tumor cells is observed not only during hypoxic state how is realized in normal cells but also during oxygenation (Warburg  effect). It is accepted that by any carcinogenic action the activation of oncogenes or inactivation of genes – supressors occurs. As a result  it is permanent expression of oncoproteins and stimulation of tumour development. Different oncoproteins operate in different regulation systems at that they cause the same effect – tumour development.

It is assumed that oncoproteins are not the ultimate factor in tumour development but there are existed some common element which is activated by different oncoproteins. In this review it is assumed that common element is HIFα (hypoxia-inducible factor α) transcription factor and it is discussed the mechanisms its activation by oncoproteins takes place in different signal systems.

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