Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press17510.17650/2313-805X-2018-5-4-72-77REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИRole of TRIM16 in cancers developmentРоль белка TRIM16 в развитии злокачественных новообразованийhttps://orcid.org/0000-0002-5269-736XSpirinaL. V.СпиринаЛ. В.
Russian Federation

5 Kooperativnyy Pereulok, Tomsk 634009; 2 Moskovskiy Trakt, Tomsk 634050

Людмила Викторовна Спирина.

634009 Томск, пер. Кооперативный 5; 634050 Томск, Московский тракт, 2

spirinalv@oncology.tomsk.ruhttps://orcid.org/0000-0003-0907-4615KondakovaI. V.КондаковаИ. В.
Russian Federation

5 Kooperativnyy Pereulok, Tomsk 634009

634009 Томск, пер. Кооперативный 5

https://orcid.org/0000-0002-3605-5009TarasenkoN. V.ТарасенкоН. В.
Russian Federation

2 Moskovskiy Trakt, Tomsk 634050; 3 Moskovskiy Tract, Tomsk 634050

634050 Томск, Московский тракт, 2; 634050, Томск, Московский тракт, 3

Саncеr Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesНИИ онкологии, ФГБНУ Томский национальный исследовательский медицинский центр РАНSiberian State Medical UniversityФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава РоссииResearch Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of SciencesНИИ медицинской генетики, ФГБНУ Томский национальный исследовательский медицинский центр РАН151220185472770301201903012019Copyright ©; 2018, Spirina L.V., Kondakova I.V., Tarasenko N.V.Copyright ©; 2018, Спирина Л.В., Кондакова И.В., Тарасенко Н.В.2018Spirina L.V., Kondakova I.V., Tarasenko N.V.Спирина Л.В., Кондакова И.В., Тарасенко Н.В.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/175

Тhe protein TRIM16 is involved in key intracellular processes, such as proliferation, cell differentiation and programmed death, including intrinsic and extrinsic apoptosis, autophagy-dependent cell death and immunogenic cell death. The TRIM16 protein acts the proteins TPD43, Gli-1, RARβ, Snail components and MAPK signaling pathway, cadherins, caspases and is also associated with the regulation  of the immune system via direct and indirect mechanisms. The influence of TRIM16 protein on the pathogenesis of hormone-dependent tumors is well-known. Further study of the TRIM16 role in the development and progression of malignant neoplasms will form the basis for  the development of new methods for predicting the course of the malignant process.

Белок TRIM16 участвует в ключевых внутриклеточных процессах, таких как пролиферация, дифференцировка клеток и программированная гибель клеток, включающая апоптоз по внутреннему и внешнему пути, аутофагию и иммунногенную гибель клеток. Действие TRIM16 по прямым и опосредованным механизмам касается белков TPD43, Gli-1, RARβ, компонентов Snail- и MAPK-сигнального пути, кадгеринов, каспаз, а также связано с регуляцией действия иммунной системы. В настоящее время выявлено значение белка TRIM16 в патогенезе гормонозависимых опухолей. Дальнейшее изучение роли белка TRIM16 в развитии и прогрессии злокачественных новообразований создаст основу для разработки новых методов прогноза течения злокачественного процесса.

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