Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press17610.17650/2313-805X-2018-5-4-78-85REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИSmall GTPase Rab3B: biological properties and possible role in carcinogenesisМалая ГТФаза Rab3B: биологические свойства и возможная роль в канцерогенезеhttps://orcid.org/0000-0002-7362-176XBudkoA. A.БудкоА. А.
Russian Federation

Faculty of Fundamental Medicine M.V. Lomonosov MSU.

24 Kashirskoe Shosse, Moscow 115478; Build. 1, 27 Lomonosovskiy Proezd, Moscow 119192

Антон Александрович Будко - факультет фундаментальной медицины МГУ им. М.В. Ломоносова

115478 Москва, Каширское шоссе, 24; 119192 Москва, Ломоносовский пр-т, 27, корп. 1

anton-budko@mail.ruKhesinaP. A.ХесинаП. А.
Russian Federation

Biological Faculty M.V. Lomonosov MSU.

24 Kashirskoe Shosse, Moscow 115478; Build. 12, 1 Leninskie Gory, Moscow 119234

Биологический факультет МГУ им. М.В. Ломоносова.

115478 Москва, Каширское шоссе, 24; 119234 Москва, Ленинские горы, 1, стр. 12

https://orcid.org/0000-0002-1972-5138DiakovL. M.ДьяковЛ. М.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0001-9560-1383LazarevichN. L.ЛазаревичН. Л.
Russian Federation

Biological Faculty M.V. Lomonosov MSU.

24 Kashirskoe Shosse, Moscow 115478; Build. 12, 1 Leninskie Gory, Moscow 119234

Биологический факультет МГУ им. М.В. Ломоносова.

115478 Москва, Каширское шоссе, 24; 119234 Москва, Ленинские горы, 1, стр. 12

Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaНИИ канцерогенеза, ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииM.V. Lomonosov Moscow State UniversityФГБОУ ВО Московский государственный университет им. М.В. ЛомоносоваM.V. Lomonosov Moscow State UniversityФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова151220185478850301201903012019Copyright ©; 2018, Budko A.A., Khesina P.A., Diakov L.M., Lazarevich N.L.Copyright ©; 2018, Будко А.А., Хесина П.А., Дьяков Л.М., Лазаревич Н.Л.2018Budko A.A., Khesina P.A., Diakov L.M., Lazarevich N.L.Будко А.А., Хесина П.А., Дьяков Л.М., Лазаревич Н.Л.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/176

Proteins of the superfamily of small guanosine triphosphate hydrolase (GTPase) perform various functions: from the control of cell proliferation to the regulation of vesicular transport. The superfamily of small GTPase Ras includes more than 150 proteins, devided to 5 major families (Arf, Ran, Rho, Ras and Rab), and plays an important role in carcinogenesis. Compared to the other families, the Rab family was investigated by relatively small number studies, which does not equally reflect their role in malignant transformation processes. In our review  we have focused on both the subfamily Rab3 and its poorly investigated member Rab3B. Recent findings allow to consider Rab3B not only  as a promising diagnostic or prognostic marker for several types of neoplasms, but also is a potential target for antitumor therapy. Our analysis of publicly available transcriptional databases revealed that kidney, lung and liver cancer patients with low Rab3B gene expression demonstrate a better overall five-year survival.

Белки суперсемейства малых гуанозинтрифосфат гидролаз (ГТФаз) выполняют различные функции: от контроля клеточной пролиферации до регуляции везикулярного транспорта. Суперсемейство малых ГТФаз Ras включает более 150 белков, 5 основных семейств (Arf, Ran, Rho, Ras и Rab) и играет важную роль в канцерогенезе. По сравнению с остальными семействами малых ГТФаз, белкам семейства Rab посвящено относительно небольшое количество исследований, что не отражает их важную роль в процессах злокачественной трансформации. Помимо рассмотрения семейства Rab в целом, особое внимание в обзоре уделено подсемейству Rab3 и его малоизученному представителю Rab3B. Накопленные к настоящему времени данные позволяют рассматривать Rab3B не только как перспективный диагностический или прогностический маркер при целом ряде новообразований, но и как потенциальную мишень для противоопухолевой терапии. Проведенный нами анализ общедоступных транскриптомных баз данных показал, что пациенты с низкой экспрессией гена Rab3B демонстрируют лучшую общую 5-летнюю выживаемость при раке почки, легкого и печени.

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