Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press17910.17650/2313-805X-2018-5-4-104-109RESEARCH ARTICLESЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИImmunohistochemical evaluation of vimentin aberrant expression in lung carcinoid tumorsИммуногистохимический анализ аберрантной экспрессии виментина в карциноидных опухолях легкогоhttps://orcid.org/0000-0002-4550-2069DelektorskayaV. V.ДелекторскаяВ. В.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

Вера Владимировна Делекторская.

115478 Москва, Каширское шоссе, 24

delektorskaya@yandex.ruChemerisG. Yu.ЧемерисГ. Ю.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-3330-337XSmirnovaE. A.СмирноваЕ. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России15122018541041090401201904012019Copyright ©; 2018, Delektorskaya V.V., Chemeris G.Y., Smirnova E.A.Copyright ©; 2018, Делекторская В.В., Чемерис Г.Ю., Смирнова Е.А.2018Delektorskaya V.V., Chemeris G.Y., Smirnova E.A.Делекторская В.В., Чемерис Г.Ю., Смирнова Е.А.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/179

Objective: to the study of the vimentin aberrant expression in the carcinoid tumors of lung, which is a rare group of epithelial neuroendocrine neoplasms with common morphological characteristics and highly variable clinical course.

Materials and methods. Vimentin expression was studied using immunohistochemical analysis in neoplasms of 34 patients with lung carcinoid tumors, which included 17 cases in the categories of typical and atypical carcinoids.

Results. Overall positive cytoplasmic immunoreactivity was observed in 9 (26.5 %) of the 34 studied tumors. Staining for vimentin was positive in 2 (11.8 %) of typical carcinoid and in 7 (41.2 %) of atypical carcinoid specimens. Expression of vimentin was more often observed  in the atypical carcinoids category and was significantly associated with increased grade (p = 0.05), and cell proliferation taking into account the Ki-67 index (p = 0.008).

Conclusion. These results suggest that expression of vimentin as an epithelial-mesenchymal transition-related marker plays an important role in the progression of carcinoid tumors. It may prove useful for diagnostic purposes, and also be used as a potential criterion for prognosis assessment of this type of tumors.

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