Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press1810.17650/2313-805X.2014.1.1.69-80REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИModern conceptions of serological tumor markers and their role in oncologyСовременные представления о серологических опухолеассоциированных маркерах и их месте в онкологииSergeevaN. S.СергееваН. С.
Russian Federation
prognoz.06@mail.ruMarshutinaN. V.МаршутинаН. В.
Russian Federation
SolokhinaM. P.СолохинаМ. П.
Russian Federation
AlentovI. I.АлентовИ. И.
Russian Federation
ParilovaN. K.ПариловаН. К.
Russian Federation
ZenkinaE. V.ЗенкинаЕ. В.
Russian Federation
SkashchkovaT. E.СкачковаТ. Е.
Russian Federation
P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of RussiaФГБУ «Московский научно-исследовательский онкологический институт им. П. А. Герцена» Минздрава РоссииN.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, MoscowГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Минздрава России, Москва150120141169800206201502062015Copyright ©; 2014, Sergeeva N.S., Marshutina N.V., Solokhina M.P., Alentov I.I., Parilova N.K., Zenkina E.V., Skashchkova T.E.Copyright ©; 2014, Сергеева Н.С., Маршутина Н.В., Солохина М.П., Алентов И.И., Парилова Н.К., Зенкина Е.В., Скачкова Т.Е.2014Sergeeva N.S., Marshutina N.V., Solokhina M.P., Alentov I.I., Parilova N.K., Zenkina E.V., Skashchkova T.E.Сергеева Н.С., Маршутина Н.В., Солохина М.П., Алентов И.И., Парилова Н.К., Зенкина Е.В., Скачкова Т.Е.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/18

The paper reviews modern concepts of serological tumor markers and their place in oncology: using for differential diagnostics, in the prognosis of the tumor, follow-up and for preclinical revealing of relapses, as well as in the screening aimed at early detection of malignant neoplasms. Biochemical characteristics and functions of most informative tumor markers (CA125, PSA etc.) were described. Currently diagnostic indexes, obtained by the in vitro diagnostic multivariate index assay (IVDMIA), and algorithms using several serological markers begin to apply in laboratory practice to increase diagnostic accuracy. Also some promising new serological tumor markers were described in this review.

Обзор посвящен современным представлениям о серологических опухолеассоциированных маркерах (ОМ) и их месте в онкологии: использовании для дифференциальной диагностики, в прогнозе течения опухолевого процесса, мониторинге и для доклинического выявления рецидивов болезни, а также в скрининге, направленном на раннее выявление злокачественных новообразований. Описаны биохимические характеристики и функции наиболее информативных ОМ (СА125, ПСА и др). В настоящее время с целью повышения диагностической точности в лабораторной практике начинают применяться диагностические индексы, полученные путем многопараметрического анализа in vitro (in vitro diagnostic multivariate index assay, IVDMIA), и алгоритмы с использованием нескольких серологических маркеров. Также в обзоре описаны некоторые новые перспективные серологические ОМ.

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