<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Advances in Molecular Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Advances in Molecular Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Успехи молекулярной онкологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2313-805X</issn><issn publication-format="electronic">2413-3787</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">2</article-id><article-id pub-id-type="doi">10.17650/2313-805X.2015.2.1.013-026</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">The role of Ikaros transcriptional factor in normal hematopoiesis and leukemogenesis: biological and clinical aspects</article-title><trans-title-group xml:lang="ru"><trans-title>Роль транскрипционного фактора Ikaros в нормальном гемопоэзе и лейкозогенезе: биологические и клинические аспекты</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vshivkoo</surname><given-names>V. S.</given-names></name><name xml:lang="ru"><surname>Вшивкова</surname><given-names>Ольга Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>43 Frunzenskaya St., v. Borovlyany, Minsk region, 223053, Belarus</p></bio><bio xml:lang="ru"><p>Беларусь, 223053, Минский район, д. Боровляны, ул. Фрунзенская, 43</p></bio><email>vshyukova@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Meleshko</surname><given-names>A. N.</given-names></name><name xml:lang="ru"><surname>Мелешко</surname><given-names>А. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>43 Frunzenskaya St., v. Borovlyany, Minsk region, 223053, Belarus</p></bio><bio xml:lang="ru"><p>Беларусь, 223053, Минский район, д. Боровляны, ул. Фрунзенская, 43</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Republican Research Center for Pediatric Oncology, Hematology and Immunology, Ministry of Health of Belarus</institution></aff><aff><institution xml:lang="ru">ГУ «Республиканский научно-практический центр детской онкологии, гематологии и иммунологии» Минздрава Республики Беларусь</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2015</year></pub-date><volume>2</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>013</fpage><lpage>026</lpage><history><date date-type="received" iso-8601-date="2015-06-01"><day>01</day><month>06</month><year>2015</year></date><date date-type="accepted" iso-8601-date="2015-06-01"><day>01</day><month>06</month><year>2015</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Vshivkoo V.S., Meleshko A.N.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, Вшивкова О.С., Мелешко А.Н.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Vshivkoo V.S., Meleshko A.N.</copyright-holder><copyright-holder xml:lang="ru">Вшивкова О.С., Мелешко А.Н.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://umo.abvpress.ru/jour/article/view/2">https://umo.abvpress.ru/jour/article/view/2</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>Ikaros</kwd><kwd>IKZF1</kwd><kwd>alternative splicing</kwd><kwd>hemoblastoses</kwd><kwd>deletions</kwd><kwd>isoforms</kwd><kwd>leukemogenesis</kwd><kwd>tumor suppressor</kwd><kwd>acute lymphoblastic leukemia</kwd><kwd>prognostic marker</kwd><kwd>transcription factor</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Ikaros</kwd><kwd>IKZF1</kwd><kwd>альтернативный сплайсинг</kwd><kwd>гемобластозы</kwd><kwd>делеции</kwd><kwd>изоформы</kwd><kwd>лейкозогенез</kwd><kwd>опухолевый супрессор</kwd><kwd>острый лимфобластный лейкоз</kwd><kwd>прогностический маркер</kwd><kwd>транскрипционный фактор</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. OriGene Technologies database. URL: http://www.origene.com / Human_cDNA / SC331775. aspx.</mixed-citation><mixed-citation xml:lang="ru">OriGene Technologies database. URL: http://www.origene.com / Human_cDNA / SC331775. aspx.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Gounari F., Kee B. L. Fingerprinting Ikaros. Nat Immunol 2013;14(10):1034–5.</mixed-citation><mixed-citation xml:lang="ru">Gounari F., Kee B. L. Fingerprinting Ikaros. Nat Immunol 2013;14(10):1034–5.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Jhanjun L., Perez-Casellas L. A., Savic A. et al. Ikaros isoforms the saga continues. World J Biol Chem 2011;2(6):140–5.</mixed-citation><mixed-citation xml:lang="ru">Jhanjun L., Perez-Casellas L. A., Savic A. et al. Ikaros isoforms the saga continues. World J Biol Chem 2011;2(6):140–5.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Molnár A., Georgopoulos K. The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol Cell Biol 1994;14(12):8292–303.</mixed-citation><mixed-citation xml:lang="ru">Molnár A., Georgopoulos K. The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol Cell Biol 1994;14(12):8292–303.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Payne K. J., Nicolas J. H., Zhu J. Y. et al.Cutting edge: predominant expression of a novel Ikaros isoform in normal human hemopoiesis. J Immunol 2001;167(4): 1867–70.</mixed-citation><mixed-citation xml:lang="ru">Payne K. J., Nicolas J. H., Zhu J. Y. et al.Cutting edge: predominant expression of a novel Ikaros isoform in normal human hemopoiesis. J Immunol 2001;167(4): 1867–70.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Meleshko A. N., Movchan L. V., Belevtsev M. V., Savitskaja T. V. Relative expression of different Ikaros isoforms in childhood acute leukemia. Blood Cells Mol Dis 2008;41(3):278–83.</mixed-citation><mixed-citation xml:lang="ru">Meleshko A. N., Movchan L. V., Belevtsev M. V., Savitskaja T. V. Relative expression of different Ikaros isoforms in childhood acute leukemia. Blood Cells Mol Dis 2008;41(3):278–83.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Georgopoulos K. Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat Rev Immunol 2002;2(3):162–74.</mixed-citation><mixed-citation xml:lang="ru">Georgopoulos K. Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat Rev Immunol 2002;2(3):162–74.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Cortes M., Wong E., Koipally J., Georgopoulos K. Control of lymphocyte development by the Ikaros gene family. Curr Opin Immunol 1999;11(2):167–71.</mixed-citation><mixed-citation xml:lang="ru">Cortes M., Wong E., Koipally J., Georgopoulos K. Control of lymphocyte development by the Ikaros gene family. Curr Opin Immunol 1999;11(2):167–71.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Liu M., Whetstine J. R., Payton S. G. et al. Roles of USF, Ikaros and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter. Biochem J 2004;383(Pt 2):249–57.</mixed-citation><mixed-citation xml:lang="ru">Liu M., Whetstine J. R., Payton S. G. et al. Roles of USF, Ikaros and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter. Biochem J 2004;383(Pt 2):249–57.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Zinc finger proteins: From atomic contact to cellular function. S. Iuchi, N. Kuldel (eds.). Landes Bioscience, 2005. P. 201.</mixed-citation><mixed-citation xml:lang="ru">Zinc finger proteins: From atomic contact to cellular function. S. Iuchi, N. Kuldel (eds.). Landes Bioscience, 2005. P. 201.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Song C., Li Z., Erbe A. K. et al. Regulation of Ikaros function by casein kinase 2 and protein phosphatase 1. World J Biol Chem 2011;2(6):126–31.</mixed-citation><mixed-citation xml:lang="ru">Song C., Li Z., Erbe A. K. et al. Regulation of Ikaros function by casein kinase 2 and protein phosphatase 1. World J Biol Chem 2011;2(6):126–31.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Francis O. L., Payne J. L., Su R. J., Payne K. J. Regulator of myeloid differentiation and function: The secret life of Ikaros. World J Biol Chem 2011;2(6):119–25.</mixed-citation><mixed-citation xml:lang="ru">Francis O. L., Payne J. L., Su R. J., Payne K. J. Regulator of myeloid differentiation and function: The secret life of Ikaros. World J Biol Chem 2011;2(6):119–25.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Schwickert T. A., Tagoh H., Gültekin S. et al. Stage-specific control of early B cell development by the transcription factor Ikaros. Nat Immunol 2014;15(3):283–93.</mixed-citation><mixed-citation xml:lang="ru">Schwickert T. A., Tagoh H., Gültekin S. et al. Stage-specific control of early B cell development by the transcription factor Ikaros. Nat Immunol 2014;15(3):283–93.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Georgopoulos K., Moore D. D., Derfler B. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science 1992;258(5083):808–12.</mixed-citation><mixed-citation xml:lang="ru">Georgopoulos K., Moore D. D., Derfler B. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science 1992;258(5083):808–12.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Georgopoulos K., Bigby M., Wang J. H. et al. The Ikaros gene is required for the development of all lymphoid lineages. Cell 1994;79(1):143–56.</mixed-citation><mixed-citation xml:lang="ru">Georgopoulos K., Bigby M., Wang J. H. et al. The Ikaros gene is required for the development of all lymphoid lineages. Cell 1994;79(1):143–56.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Winandy S., Wu P., Georgopoulos K. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 1995;83(2):289–99.</mixed-citation><mixed-citation xml:lang="ru">Winandy S., Wu P., Georgopoulos K. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 1995;83(2):289–99.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Wang J. H., Nichogiannopoulou A., Wu L. et al. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity 1996;5(6):537–49.</mixed-citation><mixed-citation xml:lang="ru">Wang J. H., Nichogiannopoulou A., Wu L. et al. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity 1996;5(6):537–49.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Ярилин А. А. Иммунология. М.: ГЭОТАР-Медиа, 2010. 752 c. [Yarilin A. A. Immunology. Moscow: GEOTAR-Media, 2010. 752 p. (In Russ.)].</mixed-citation><mixed-citation xml:lang="ru">Ярилин А. А. Иммунология. М.: ГЭОТАР-Медиа, 2010. 752 c. [Yarilin A. A. Immunology. Moscow: GEOTAR-Media, 2010. 752 p. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Sellars M., Kastner P., Chan S. Ikaros in B cell development and function. World J Biol Chem 2011;2(6):132–39.</mixed-citation><mixed-citation xml:lang="ru">Sellars M., Kastner P., Chan S. Ikaros in B cell development and function. World J Biol Chem 2011;2(6):132–39.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Yoshida T., Georgopoulos K. Ikaros fingers on lymphocyte differentiation. Int J Hematol 2014;100(3):220–9.</mixed-citation><mixed-citation xml:lang="ru">Yoshida T., Georgopoulos K. Ikaros fingers on lymphocyte differentiation. Int J Hematol 2014;100(3):220–9.</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">21. Osborne B. A. Transcriptional control of T cell development. Curr Opin Immunol 2000;12(3):301–6.</mixed-citation><mixed-citation xml:lang="ru">Osborne B. A. Transcriptional control of T cell development. Curr Opin Immunol 2000;12(3):301–6.</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">22. Rothenberg E. V., Taghon T. Molecular genetics of T cell development. Annu Rev Immunol 2005;23:601–49.</mixed-citation><mixed-citation xml:lang="ru">Rothenberg E. V., Taghon T. Molecular genetics of T cell development. Annu Rev Immunol 2005;23:601–49.</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">23. Winandy S. Ikaros to the rescue of TCR-α chain gene rearrangement. Eur J Immunol 2013;43(2):314–7.</mixed-citation><mixed-citation xml:lang="ru">Winandy S. Ikaros to the rescue of TCR-α chain gene rearrangement. Eur J Immunol 2013;43(2):314–7.</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">24. Schmitt C., Tonnelle C., Dalloul A. et al. Aiolos and Ikaros: regulators of lymphocyte development, homeostasis and lymphoproliferation. Apoptosis 2002;7(3):277–84.</mixed-citation><mixed-citation xml:lang="ru">Schmitt C., Tonnelle C., Dalloul A. et al. Aiolos and Ikaros: regulators of lymphocyte development, homeostasis and lymphoproliferation. Apoptosis 2002;7(3):277–84.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><citation-alternatives><mixed-citation xml:lang="en">25. Avitahl N., Winandy S., Friedrich C. et al. Ikaros sets thresholds for T cell activation and regulates chromosome propagation. Immunity 1999;10(3):333–43.</mixed-citation><mixed-citation xml:lang="ru">Avitahl N., Winandy S., Friedrich C. et al. Ikaros sets thresholds for T cell activation and regulates chromosome propagation. Immunity 1999;10(3):333–43.</mixed-citation></citation-alternatives></ref><ref id="B26"><label>26.</label><citation-alternatives><mixed-citation xml:lang="en">26. Tinsley K. W., Hong C., Luckey M. A. et al. Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus. Blood 2013;122(14):2358–68.</mixed-citation><mixed-citation xml:lang="ru">Tinsley K. W., Hong C., Luckey M. A. et al. Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus. Blood 2013;122(14):2358–68.</mixed-citation></citation-alternatives></ref><ref id="B27"><label>27.</label><citation-alternatives><mixed-citation xml:lang="en">27. Yoshida T., Ng S. Y., Zuniga-Pflucker J. C., Georgopoulos K. Early hematopoietic lineage restrictions directed by Ikaros. Nat Immunol 2006;7(4):382–91.</mixed-citation><mixed-citation xml:lang="ru">Yoshida T., Ng S. Y., Zuniga-Pflucker J. C., Georgopoulos K. Early hematopoietic lineage restrictions directed by Ikaros. Nat Immunol 2006;7(4):382–91.</mixed-citation></citation-alternatives></ref><ref id="B28"><label>28.</label><citation-alternatives><mixed-citation xml:lang="en">28. Ng S. Y., Yoshida T., Zhang J., Georgopoulos K. Genome-wide lineagespecific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity 2009;30(4):493‑507.</mixed-citation><mixed-citation xml:lang="ru">Ng S. Y., Yoshida T., Zhang J., Georgopoulos K. Genome-wide lineagespecific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity 2009;30(4):493‑507.</mixed-citation></citation-alternatives></ref><ref id="B29"><label>29.</label><citation-alternatives><mixed-citation xml:lang="en">29. Nutt S. L., Kee B. L. The transcriptional regulation of B cell lineage commitment. Immunity 2007;26(6):715–25.</mixed-citation><mixed-citation xml:lang="ru">Nutt S. L., Kee B. L. The transcriptional regulation of B cell lineage commitment. Immunity 2007;26(6):715–25.</mixed-citation></citation-alternatives></ref><ref id="B30"><label>30.</label><citation-alternatives><mixed-citation xml:lang="en">30. Smith E., Sigvardsson M. The roles of transcription factors in B lymphocyte commitment, development, and transformation. J Leukoc Biol 2004;75(6):973–81.</mixed-citation><mixed-citation xml:lang="ru">Smith E., Sigvardsson M. The roles of transcription factors in B lymphocyte commitment, development, and transformation. J Leukoc Biol 2004;75(6):973–81.</mixed-citation></citation-alternatives></ref><ref id="B31"><label>31.</label><citation-alternatives><mixed-citation xml:lang="en">31. Ng S. Y., Yoshida T., Georgopoulos K. Ikaros and chromatin regulation in early hematopoiesis. Curr Opin Immunol 2007;19(2):116–22.</mixed-citation><mixed-citation xml:lang="ru">Ng S. Y., Yoshida T., Georgopoulos K. Ikaros and chromatin regulation in early hematopoiesis. Curr Opin Immunol 2007;19(2):116–22.</mixed-citation></citation-alternatives></ref><ref id="B32"><label>32.</label><citation-alternatives><mixed-citation xml:lang="en">32. Kirstetter P., Thomas M., Dierich A. et al. Ikaros is critical for B cell differentiation and function. Eur J Immunol 2002;32(3):720–30.</mixed-citation><mixed-citation xml:lang="ru">Kirstetter P., Thomas M., Dierich A. et al. Ikaros is critical for B cell differentiation and function. Eur J Immunol 2002;32(3):720–30.</mixed-citation></citation-alternatives></ref><ref id="B33"><label>33.</label><citation-alternatives><mixed-citation xml:lang="en">33. Liberg D., Smale S. T., Merkenschlager M. Upstream of Ikaros. Trends Immunol 2003;24(11):567–70.</mixed-citation><mixed-citation xml:lang="ru">Liberg D., Smale S. T., Merkenschlager M. Upstream of Ikaros. Trends Immunol 2003;24(11):567–70.</mixed-citation></citation-alternatives></ref><ref id="B34"><label>34.</label><citation-alternatives><mixed-citation xml:lang="en">34. Jäger R., Gisslinger H., Passamonti F. et al. Deletions of the transcription factor Ikaros in myeloproliferative neoplasms. Leukemia 2010;24(7):1290–8.</mixed-citation><mixed-citation xml:lang="ru">Jäger R., Gisslinger H., Passamonti F. et al. Deletions of the transcription factor Ikaros in myeloproliferative neoplasms. Leukemia 2010;24(7):1290–8.</mixed-citation></citation-alternatives></ref><ref id="B35"><label>35.</label><citation-alternatives><mixed-citation xml:lang="en">35. Tefferi A. Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1. Leukemia 2010;24(60):1128–38.</mixed-citation><mixed-citation xml:lang="ru">Tefferi A. Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1. Leukemia 2010;24(60):1128–38.</mixed-citation></citation-alternatives></ref><ref id="B36"><label>36.</label><citation-alternatives><mixed-citation xml:lang="en">36. Yagi T., Hibi S., Takanashi M. et al. High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis. Blood 2002;99(4):1350–5.</mixed-citation><mixed-citation xml:lang="ru">Yagi T., Hibi S., Takanashi M. et al. High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis. Blood 2002;99(4):1350–5.</mixed-citation></citation-alternatives></ref><ref id="B37"><label>37.</label><citation-alternatives><mixed-citation xml:lang="en">37. Meyer C., Zur Stadt U., Escherich G. et al. Refinement of IKZF1 recombination hotspots in pediatric BCP-ALL patients. Am J Blood Res 2013;3(2):165–73.</mixed-citation><mixed-citation xml:lang="ru">Meyer C., Zur Stadt U., Escherich G. et al. Refinement of IKZF1 recombination hotspots in pediatric BCP-ALL patients. Am J Blood Res 2013;3(2):165–73.</mixed-citation></citation-alternatives></ref><ref id="B38"><label>38.</label><citation-alternatives><mixed-citation xml:lang="en">38. Klein F., Feldhahn N., Herzog S. et al. BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells. Oncogene 2006;25(7):1118–24.</mixed-citation><mixed-citation xml:lang="ru">Klein F., Feldhahn N., Herzog S. et al. BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells. Oncogene 2006;25(7):1118–24.</mixed-citation></citation-alternatives></ref><ref id="B39"><label>39.</label><citation-alternatives><mixed-citation xml:lang="en">39. Mullighan C. G., Miller C. B., Radtke I. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 2008;453(7191):110–4.</mixed-citation><mixed-citation xml:lang="ru">Mullighan C. G., Miller C. B., Radtke I. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 2008;453(7191):110–4.</mixed-citation></citation-alternatives></ref><ref id="B40"><label>40.</label><citation-alternatives><mixed-citation xml:lang="en">40. Yuan T., Zhao X. L., Zhang L. X. et al. Expression and clinical significance of IKZF1 gene IK6 isoform in adult acute lymphoblastic leukemia. J Exp Hematol 2013;21(3):539–43.</mixed-citation><mixed-citation xml:lang="ru">Yuan T., Zhao X. L., Zhang L. X. et al. Expression and clinical significance of IKZF1 gene IK6 isoform in adult acute lymphoblastic leukemia. J Exp Hematol 2013;21(3):539–43.</mixed-citation></citation-alternatives></ref><ref id="B41"><label>41.</label><citation-alternatives><mixed-citation xml:lang="en">41. Burmeister T., Gesine B., Gröger D. Germline variants in IKZF1, ARID5B, and CEBPE as risk factors for adult-onset acute lymphoblastic leukemia: an analysis from the GMALL study group. Haematologica 2014;99(2):e23–5.</mixed-citation><mixed-citation xml:lang="ru">Burmeister T., Gesine B., Gröger D. Germline variants in IKZF1, ARID5B, and CEBPE as risk factors for adult-onset acute lymphoblastic leukemia: an analysis from the GMALL study group. Haematologica 2014;99(2):e23–5.</mixed-citation></citation-alternatives></ref><ref id="B42"><label>42.</label><citation-alternatives><mixed-citation xml:lang="en">42. Mullighan C. G. The molecular genetic makeup of acute lymphoblastic leukemia. Hematology Am Soc Hematol Educ Program 2012;2012:389–96. doi: 10.1182 / asheducation-2012.1.389.</mixed-citation><mixed-citation xml:lang="ru">Mullighan C. G. The molecular genetic makeup of acute lymphoblastic leukemia. Hematology Am Soc Hematol Educ Program 2012;2012:389–96. doi: 10.1182 / asheducation-2012.1.389.</mixed-citation></citation-alternatives></ref><ref id="B43"><label>43.</label><citation-alternatives><mixed-citation xml:lang="en">43. Mullighan C. G., Goorha S., Radtke I. et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007;446(7137):758–64.</mixed-citation><mixed-citation xml:lang="ru">Mullighan C. G., Goorha S., Radtke I. et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007;446(7137):758–64.</mixed-citation></citation-alternatives></ref><ref id="B44"><label>44.</label><citation-alternatives><mixed-citation xml:lang="en">44. Kawamata N., Ogawa S., Zimmermann M. et al. Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray. Blood 2008;111(2):776–84.</mixed-citation><mixed-citation xml:lang="ru">Kawamata N., Ogawa S., Zimmermann M. et al. Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray. Blood 2008;111(2):776–84.</mixed-citation></citation-alternatives></ref><ref id="B45"><label>45.</label><citation-alternatives><mixed-citation xml:lang="en">45. Paulsson K., Cazier J. B., Macdougall F. Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease. Proc Natl Acad Sci USA 2008;105(18):6708–13.</mixed-citation><mixed-citation xml:lang="ru">Paulsson K., Cazier J. B., Macdougall F. Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease. Proc Natl Acad Sci USA 2008;105(18):6708–13.</mixed-citation></citation-alternatives></ref><ref id="B46"><label>46.</label><citation-alternatives><mixed-citation xml:lang="en">46. Martinelli G., Iacobucci I., Storlazzi C. T. et al. IKZF1(Ikaros) deletions in BCRABL1‑positive acute lymphoblastic leukemia are associated with short diseasefree survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report. J Clin Oncol 2009;27(31):5202–7.</mixed-citation><mixed-citation xml:lang="ru">Martinelli G., Iacobucci I., Storlazzi C. T. et al. IKZF1(Ikaros) deletions in BCRABL1‑positive acute lymphoblastic leukemia are associated with short diseasefree survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report. J Clin Oncol 2009;27(31):5202–7.</mixed-citation></citation-alternatives></ref><ref id="B47"><label>47.</label><citation-alternatives><mixed-citation xml:lang="en">47. Mullighan C. G., Su X., Zhang J. et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009;360(5):470–80.</mixed-citation><mixed-citation xml:lang="ru">Mullighan C. G., Su X., Zhang J. et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009;360(5):470–80.</mixed-citation></citation-alternatives></ref><ref id="B48"><label>48.</label><citation-alternatives><mixed-citation xml:lang="en">48. Den Boer M. L., van Slegtenhorst M., de Menezes R. X. et al. A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol 2009;10(2):125–34.</mixed-citation><mixed-citation xml:lang="ru">Den Boer M. L., van Slegtenhorst M., de Menezes R. X. et al. A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol 2009;10(2):125–34.</mixed-citation></citation-alternatives></ref><ref id="B49"><label>49.</label><citation-alternatives><mixed-citation xml:lang="en">49. Okamoto R., Ogawa S., Nowak D. et al. Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. Haematologica 2010;95(9):1481–8.</mixed-citation><mixed-citation xml:lang="ru">Okamoto R., Ogawa S., Nowak D. et al. Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. Haematologica 2010;95(9):1481–8.</mixed-citation></citation-alternatives></ref><ref id="B50"><label>50.</label><citation-alternatives><mixed-citation xml:lang="en">50. Iacobucci I., Iraci N., Messina M. et al. IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia. PLoS One 2012;7(7):e40934.</mixed-citation><mixed-citation xml:lang="ru">Iacobucci I., Iraci N., Messina M. et al. IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia. PLoS One 2012;7(7):e40934.</mixed-citation></citation-alternatives></ref><ref id="B51"><label>51.</label><citation-alternatives><mixed-citation xml:lang="en">51. Caye A., Beldjord K., Mass-Malo K. et al. Breakpoint-specific multiplex polymerase chain reaction allows the detection of IKZF1 intragenic deletions and minimal residual disease monitoring in B-cell precursor acute lymphoblastic leukemia. Haematologica 2013;98(4): 597–601.</mixed-citation><mixed-citation xml:lang="ru">Caye A., Beldjord K., Mass-Malo K. et al. Breakpoint-specific multiplex polymerase chain reaction allows the detection of IKZF1 intragenic deletions and minimal residual disease monitoring in B-cell precursor acute lymphoblastic leukemia. Haematologica 2013;98(4): 597–601.</mixed-citation></citation-alternatives></ref><ref id="B52"><label>52.</label><citation-alternatives><mixed-citation xml:lang="en">52. Tokunaga K., Yamaguchi S., Iwanaga E. et al. High frequency of IKZF1 genetic alterations in adult patients with B-cell acute lymphoblastic leukemia. Eur J Haematol 2013;91(3):201–8.</mixed-citation><mixed-citation xml:lang="ru">Tokunaga K., Yamaguchi S., Iwanaga E. et al. High frequency of IKZF1 genetic alterations in adult patients with B-cell acute lymphoblastic leukemia. Eur J Haematol 2013;91(3):201–8.</mixed-citation></citation-alternatives></ref><ref id="B53"><label>53.</label><citation-alternatives><mixed-citation xml:lang="en">53. de Rooij J., Beuling E., Zwaan C. M. et al. IKZF1 deletions in pediatric acute myeloid leukemia. 56th ASH Annual Meeting &amp; Exposition. URL: https://ash.confex.com / as h / 2014 / webprogram / Paper71902. html.</mixed-citation><mixed-citation xml:lang="ru">de Rooij J., Beuling E., Zwaan C. M. et al. IKZF1 deletions in pediatric acute myeloid leukemia. 56th ASH Annual Meeting &amp; Exposition. URL: https://ash.confex.com / as h / 2014 / webprogram / Paper71902. html.</mixed-citation></citation-alternatives></ref><ref id="B54"><label>54.</label><citation-alternatives><mixed-citation xml:lang="en">54. Kastner P., Chan S. Role of Ikaros in T-cell acute lymphoblastic leukemia. World J Biol Chem 2011;2(6):108–14.</mixed-citation><mixed-citation xml:lang="ru">Kastner P., Chan S. Role of Ikaros in T-cell acute lymphoblastic leukemia. World J Biol Chem 2011;2(6):108–14.</mixed-citation></citation-alternatives></ref><ref id="B55"><label>55.</label><citation-alternatives><mixed-citation xml:lang="en">55. Iacobucci I., Storlazzi C. T., Cilloni D. Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1‑positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell»Adulto Acute Leukemia Working Party(GIMEMA AL WP). Blood 2009;114(10):2159–67.</mixed-citation><mixed-citation xml:lang="ru">Iacobucci I., Storlazzi C. T., Cilloni D. Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1‑positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell»Adulto Acute Leukemia Working Party(GIMEMA AL WP). Blood 2009;114(10):2159–67.</mixed-citation></citation-alternatives></ref><ref id="B56"><label>56.</label><citation-alternatives><mixed-citation xml:lang="en">56. Roberts K. G., Morin R. D., Zhang J. et al. Genetic alterations activating kinase and cytokine receptor signaling in highrisk acute lymphoblastic leukemia. Cancer Cell 2012;22(2):153–66.</mixed-citation><mixed-citation xml:lang="ru">Roberts K. G., Morin R. D., Zhang J. et al. Genetic alterations activating kinase and cytokine receptor signaling in highrisk acute lymphoblastic leukemia. Cancer Cell 2012;22(2):153–66.</mixed-citation></citation-alternatives></ref><ref id="B57"><label>57.</label><citation-alternatives><mixed-citation xml:lang="en">57. Boehm V., Lebenatus A., Bartels M. et al. Subclonal IKZF1 deletions indicate a multiclonal evolution in BCRABL1‑positive B-cell precursor ALL. Blood 2013;122(21):1327.</mixed-citation><mixed-citation xml:lang="ru">Boehm V., Lebenatus A., Bartels M. et al. Subclonal IKZF1 deletions indicate a multiclonal evolution in BCRABL1‑positive B-cell precursor ALL. Blood 2013;122(21):1327.</mixed-citation></citation-alternatives></ref><ref id="B58"><label>58.</label><citation-alternatives><mixed-citation xml:lang="en">58. Kuiper R. P., Waanders E., van der Velden V. H. et al. IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL. Leukemia 2010;24(7):1258–64.</mixed-citation><mixed-citation xml:lang="ru">Kuiper R. P., Waanders E., van der Velden V. H. et al. IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL. Leukemia 2010;24(7):1258–64.</mixed-citation></citation-alternatives></ref><ref id="B59"><label>59.</label><citation-alternatives><mixed-citation xml:lang="en">59. Liu P., Lin Z., Qian S. et al. Expression of dominant-negative Ikaros isoforms and associated genetic alterations in Chinese adult patients with leukemia Ann Hematol 2012;91(7):1039–49.</mixed-citation><mixed-citation xml:lang="ru">Liu P., Lin Z., Qian S. et al. Expression of dominant-negative Ikaros isoforms and associated genetic alterations in Chinese adult patients with leukemia Ann Hematol 2012;91(7):1039–49.</mixed-citation></citation-alternatives></ref><ref id="B60"><label>60.</label><citation-alternatives><mixed-citation xml:lang="en">60. Mi J. Q., Wang X., Yao Y. et al. Newly diagnosed acute lymphoblastic leukemia in China(II): prognosis related to genetic abnormalities in a series of 1091 cases. Leukemia 2012;26(7):1507–16.</mixed-citation><mixed-citation xml:lang="ru">Mi J. Q., Wang X., Yao Y. et al. Newly diagnosed acute lymphoblastic leukemia in China(II): prognosis related to genetic abnormalities in a series of 1091 cases. Leukemia 2012;26(7):1507–16.</mixed-citation></citation-alternatives></ref><ref id="B61"><label>61.</label><citation-alternatives><mixed-citation xml:lang="en">61. Palmi C., Valsecchi M. G., Longinotti G. et al. What is the relevance of Ikaros gene deletions as a prognostic marker in pediatric philadelphia-negative B-cell precursor acute lymphoblastic leukemia? Haematologica 2013;98(8):1226–31.</mixed-citation><mixed-citation xml:lang="ru">Palmi C., Valsecchi M. G., Longinotti G. et al. What is the relevance of Ikaros gene deletions as a prognostic marker in pediatric philadelphia-negative B-cell precursor acute lymphoblastic leukemia? Haematologica 2013;98(8):1226–31.</mixed-citation></citation-alternatives></ref><ref id="B62"><label>62.</label><citation-alternatives><mixed-citation xml:lang="en">62. Waanders E., van der Velden V. H., van der Schoot C. E. et al. Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79 % of relapses in pediatric acute lymphoblastic leukemia. Leukemia 2011;25(2):254–8.</mixed-citation><mixed-citation xml:lang="ru">Waanders E., van der Velden V. H., van der Schoot C. E. et al. Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79 % of relapses in pediatric acute lymphoblastic leukemia. Leukemia 2011;25(2):254–8.</mixed-citation></citation-alternatives></ref><ref id="B63"><label>63.</label><citation-alternatives><mixed-citation xml:lang="en">63. Krentz S., Hof J., Mendioroz A. et al. Prognostic value of genetic alterations in children with first bone marrow relapse precursor acute lymphoblastic leukemia. Leukemia 2013;27(2):295–304.</mixed-citation><mixed-citation xml:lang="ru">Krentz S., Hof J., Mendioroz A. et al. Prognostic value of genetic alterations in children with first bone marrow relapse precursor acute lymphoblastic leukemia. Leukemia 2013;27(2):295–304.</mixed-citation></citation-alternatives></ref><ref id="B64"><label>64.</label><citation-alternatives><mixed-citation xml:lang="en">64. Martinelli G., Iacobucci I., Papayannidis C., Soverini S. New targets for Ph+ leukaemia therapy. Best Pract Res Clin Haematol 2009;22(3):445–54.</mixed-citation><mixed-citation xml:lang="ru">Martinelli G., Iacobucci I., Papayannidis C., Soverini S. New targets for Ph+ leukaemia therapy. Best Pract Res Clin Haematol 2009;22(3):445–54.</mixed-citation></citation-alternatives></ref><ref id="B65"><label>65.</label><citation-alternatives><mixed-citation xml:lang="en">65. Iacobucci I., Lonetti A., Messa F. et al. Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance. Blood 2008;112(9):3847–55.</mixed-citation><mixed-citation xml:lang="ru">Iacobucci I., Lonetti A., Messa F. et al. Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance. Blood 2008;112(9):3847–55.</mixed-citation></citation-alternatives></ref><ref id="B66"><label>66.</label><citation-alternatives><mixed-citation xml:lang="en">66. Zhou F., Xu Y., Qiu Y. et al. Ik6 expression provides a new strategy for the therapy of acute lymphoblastic leukemia. Oncol Rep 2014;31(3):1373–9.</mixed-citation><mixed-citation xml:lang="ru">Zhou F., Xu Y., Qiu Y. et al. Ik6 expression provides a new strategy for the therapy of acute lymphoblastic leukemia. Oncol Rep 2014;31(3):1373–9.</mixed-citation></citation-alternatives></ref><ref id="B67"><label>67.</label><citation-alternatives><mixed-citation xml:lang="en">67. Vitanza N. A., Zaky W., Blum R. et al. Ikaros deletions in BCR-ABL-negative childhood acute lymphoblastic leukemia are associated with a distinct gene expression signature but do not result in intrinsic chemoresistance. Pediatr Blood Cancer 2014; 61(10):1779–85.</mixed-citation><mixed-citation xml:lang="ru">Vitanza N. A., Zaky W., Blum R. et al. Ikaros deletions in BCR-ABL-negative childhood acute lymphoblastic leukemia are associated with a distinct gene expression signature but do not result in intrinsic chemoresistance. Pediatr Blood Cancer 2014; 61(10):1779–85.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
