Advances in Molecular OncologyAdvances in Molecular OncologyУспехи молекулярной онкологии2313-805X2413-3787Publishing House ABV Press20210.17650/2313-805X-2019-6-1-10-17REVIEW ARTICLESОБЗОРНЫЕ СТАТЬИAutoantibodies against tumor-associated antigens as one class of serological markersАутоантитела против опухолеассоциированных антигенов как класс серологических маркеровhttps://orcid.org/0000-0003-2997-4936MarshutinaN. V.МаршутинаН. В.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284.

125284 Москва, 2-й Боткинский проезд, 3.

https://orcid.org/0000-0001-7406-9973SergeevaN. S.СергееваН. С.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284; 1 Ostrovityanova St., Moscow 117997.

125284 Москва, 2-й Боткинский проезд, 3; 119049 Москва, ул. Островитянова, 1.

https://orcid.org/0000-0002-5920-5823AlentovI. I.АлентовИ. И.
Russian Federation

P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of Russia

 

Алентов Игорь Игоревич. 

125284 Москва, 2-й Боткинский проезд, 3.

https://orcid.org/0000-0001-8784-8415KaprinA. D.КапринА. Д.
Russian Federation

3 2nd Botkinskiy Proezd, Moscow 125284.

 

125284 Москва, 2-й Боткинский проезд, 3.

P.A. Hertzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Center, Ministry of Health of RussiaМосковский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииN.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia.Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России3 2nd Botkinskiy Proezd, Moscow 125284.Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России150120196110172704201927042019Copyright ©; 2019, Marshutina N.V., Sergeeva N.S., Alentov I.I., Kaprin A.D.Copyright ©; 2019, Маршутина Н.В., Сергеева Н.С., Алентов И.И., Каприн А.Д.2019Marshutina N.V., Sergeeva N.S., Alentov I.I., Kaprin A.D.Маршутина Н.В., Сергеева Н.С., Алентов И.И., Каприн А.Д.https://creativecommons.org/licenses/by/4.0https://umo.abvpress.ru/jour/article/view/202

This review is devoted to modern notions about autoantibodies (AAb) as one of classes of tumor biomarkers. Principles of humoral response by way of autoantibodies to different tumor-associated proteins in the process of malignant tumor progression are considered. During carcinogenesis self-proteins may become overexpressed, mutant, undergo posttranslational modification, localize abnormally, degrade aberrantly, becoming immunogenic and, as a result, be recognized by immune system as allogeneic. Advantages of AAb as biomarkers over its ligands – tumor antigens – are discussed.

Data regarding a diagnostic value of some AAb are given, modern methods of its assessment are considered. Possibilities of AAb using in screening, aimed at active diagnostics of cancer on early stages as well as 

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